VAPA

VAPA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2RR3
Identifiers
Aliases	VAPA, VAP-33, VAP-A, VAP33, hVAP-33, VAMP associated protein A, VAMP-A
External IDs	OMIM: 605703 MGI: 1353561 HomoloGene: 37824 GeneCards: VAPA
Gene location (Human)
Chr.	Chromosome 18 (human)
End	9,960,021 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	65,920,550 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; optic nerve; ; right adrenal gland; ; left adrenal gland; ; pons; ; parotid gland; ; rectum; ; islet of Langerhans; ; bronchial epithelial cell; ; right ventricle;
	Top expressed in
	Paneth cell; ; medullary collecting duct; ; renal corpuscle; ; atrioventricular valve; ; cumulus cell; ; condyle; ; fossa; ; substantia nigra; ; motor neuron; ; trigeminal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; microtubule binding; signal transducer activity; protein binding; protein heterodimerization activity; cadherin binding; FFAT motif binding;
Cellular component	integral component of membrane; vesicle; endoplasmic reticulum membrane; membrane; microtubule cytoskeleton; endoplasmic reticulum; perinuclear region of cytoplasm; endoplasmic reticulum exit site; cell junction; bicellular tight junction; Golgi membrane; nuclear membrane; nucleus; plasma membrane; azurophil granule membrane;
Biological process	COPII-coated vesicle budding; cell death; membrane fusion; protein folding in endoplasmic reticulum; sphingolipid biosynthetic process; endoplasmic reticulum organization; positive regulation by host of viral genome replication; endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of I-kappaB kinase/NF-kappaB signaling; protein localization to endoplasmic reticulum; negative regulation by host of viral genome replication; neuron projection development; signal transduction; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	9218
	30960
	ENSG00000101558
	ENSMUSG00000024091
	Q9P0L0
	Q9WV55
	NM_003574; NM_194434
	NM_013933; NM_001355402
	NP_003565; NP_919415
	NP_038961; NP_001342331
	Wikidata
View/Edit Human	View/Edit Mouse

Vesicle-associated membrane protein-associated protein A is a protein that in humans is encoded by the VAPA gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

VAPA has been shown to interact with OSBP.^[8] This interaction is mediated by the FFAT motif in OSBP.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101558 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024091 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nishimura Y, Hayashi M, Inada H, Tanaka T (Feb 1999). "Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins". Biochem Biophys Res Commun. 254 (1): 21–6. doi:10.1006/bbrc.1998.9876. PMID 9920726.
^ Weir ML, Klip A, Trimble WS (Sep 1998). "Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP". Biochem J. 333 (2): 247–51. doi:10.1042/bj3330247. PMC 1219579. PMID 9657962.
^ "Entrez Gene: VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa".
^ Wyles, Jessica P; McMaster Christopher R; Ridgway Neale D (Aug 2002). "Vesicle-associated membrane protein-associated protein-A (VAP-A) interacts with the oxysterol-binding protein to modify export from the endoplasmic reticulum". J. Biol. Chem. 277 (33). United States: 29908–18. doi:10.1074/jbc.M201191200. ISSN 0021-9258. PMID 12023275. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)CS1 maint: unflagged free DOI (link)

Interactions

References

Further reading