VPS24

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CHMP3
Protein VPS24 PDB 2gd5.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CHMP3, NEDF, VPS24, CGI-149, charged multivesicular body protein 3
External IDs MGI: 1913950 HomoloGene: 6368 GeneCards: CHMP3
RNA expression pattern
PBB GE VPS24 217837 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001005753
NM_001193517
NM_016079

NM_025783

RefSeq (protein)

NP_001185883
NP_001005753
NP_001180446
NP_057163

NP_080059.2
NP_080059

Location (UCSC) Chr 2: 86.5 – 86.56 Mb Chr 6: 71.54 – 71.58 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Charged multivesicular body protein 3 is a protein that in humans is encoded by the VPS24 gene.[3][4][5]

Function[edit]

This gene encodes a protein that acts in the sorting of transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants encoding different isoforms.[5]

Interactions[edit]

VPS24 has been shown to interact with IGFBP7.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Wilson EM, Oh Y, Hwa V, Rosenfeld RG (Sep 2001). "Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells". J Clin Endocrinol Metab. 86 (9): 4504–11. doi:10.1210/jc.86.9.4504. PMID 11549700. 
  4. ^ Whitley P, Reaves BJ, Hashimoto M, Riley AM, Potter BV, Holman GD (Sep 2003). "Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization". J Biol Chem. 278 (40): 38786–95. doi:10.1074/jbc.M306864200. PMID 12878588. 
  5. ^ a b "Entrez Gene: VPS24 vacuolar protein sorting 24 homolog (S. cerevisiae)". 

Further reading[edit]