Vasicine

Vasicine
Names
	IUPAC name 1,2,3,9-Tetrahydropyrrolo[2,1-b]quinazolin-3-ol
	Other names Peganine
Identifiers
CAS Number	6159-56-4;
3D model (JSmol)	Interactive image;
PubChem CID	72610;
CompTox Dashboard (EPA)	DTXSID701317988 ;
	SMILES C1CN2CC3=CC=CC=C3N=C2C1O;
Properties
Chemical formula	C11H12N2O
Molar mass	188.230 g·mol−1
Melting point	210 °C (410 °F; 483 K)
Solubility in acetone, alcohol, chloroform	Soluble
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Vasicine (peganine) is a quinazoline alkaloid. It is the active compound of Justicia adhatoda, after which the chemical is named.

Vasicine has been compared to theophylline both in vitro and in vivo.^[1] It has also been studied in combination with the related alkaloid vasicinone. Both the alkaloids in combination (1:1) showed pronounced bronchodilatory activity in vivo and in vitro.^[2] Both alkaloids are also respiratory stimulants.^[2] Vasicine has a cardiac–depressant effect, while vasicinone is a weak cardiac stimulant; the effect can be normalized by combining the alkaloids.^[2]^[3] Vasicine is reported to have a uterine stimulant effect.^[3]

References

^ Nepali, Kunal; Sharma, Sahil; Ojha, Ritu; Dhar, Kanaya Lal (2012). "Vasicine and structurally related quinazolines". Medicinal Chemistry Research. 22 (1): 1–15. doi:10.1007/s00044-012-0002-5. ISSN 1054-2523.
^ ^a ^b ^c Avula, B.; et al. (2008). "Quantitative determination of vasicine and vasicinone in Adhatoda vasica by high performance capillary electrophoresis" (PDF). Die Pharmazie – An International Journal of Pharmaceutical Sciences. 63 (1): 20–22. doi:10.1691/ph.2008.7175.
^ ^a ^b Rajani, M; Soni, S; Anandjiwala, Sheetal; Patel, G (2008). "Validation of different methods of preparation of Adhatoda vasica leaf juice by quantification of total alkaloids and vasicine". Indian Journal of Pharmaceutical Sciences. 70 (1): 36. doi:10.4103/0250-474X.40329. ISSN 0250-474X.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[NepaliSharma2012-1] Nepali, Kunal; Sharma, Sahil; Ojha, Ritu; Dhar, Kanaya Lal (2012). "Vasicine and structurally related quinazolines". Medicinal Chemistry Research. 22 (1): 1–15. doi:10.1007/s00044-012-0002-5. ISSN 1054-2523.

[avula2008-2] Avula, B.; et al. (2008). "Quantitative determination of vasicine and vasicinone in Adhatoda vasica by high performance capillary electrophoresis" (PDF). Die Pharmazie – An International Journal of Pharmaceutical Sciences. 63 (1): 20–22. doi:10.1691/ph.2008.7175.

[RajaniSoni2008-3] Rajani, M; Soni, S; Anandjiwala, Sheetal; Patel, G (2008). "Validation of different methods of preparation of Adhatoda vasica leaf juice by quantification of total alkaloids and vasicine". Indian Journal of Pharmaceutical Sciences. 70 (1): 36. doi:10.4103/0250-474X.40329. ISSN 0250-474X.{{cite journal}}: CS1 maint: unflagged free DOI (link)

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