Sympathetic nerve fibers travel around the tunica media of the artery, secrete neurotransmitters such as norepinephrine into the extracellular fluid surrounding the smooth muscle (tunica media) from the terminal knob of the axon. The smooth muscle cell membranes have α and β-adrenergic receptors for these neurotransmitters. Activation of α-adrenergic receptors promotes vasoconstriction, while the activation of β-adrenergic receptors mediates the relaxation of muscle cells, resulting in vasodilation. Normally, α-adrenergic receptors predominates in smooth muscle of resistance vessels.
Endothelium derived chemicals
Some vasoactive chemicals such as vasodilator acetylcholine are known for causing reduced/increased blood flow in the tumours by vasomotor changes. Inadequate blood supply to the tumour cells can cause the cells to be radio-resistant and resulted in reduced accessibility to chemotherapeutic agents.
Injuries to nerves of the lower trunk of the brachial plexus (Klumpke's paralysis) and compression of median nerve at the flexor retinaculum of the hand (Carpal Tunnel Syndrome) can cause vasomotor changes at the areas innervated by the nerves. This area of the skin will become warmer because of vasodilation (loss of vasoconstriction).
- "Vasomotor" at Dorland's Medical Dictionary
- WebMD (2009). "vasomotor". Webster's New World Medical Dictionary (3rd ed.). Houghton Mifflin Harcourt. p. 447. ISBN 978-0-544-18897-6.
- Robert C. Ward et al. (2002). In Foundations for osteopathic medicine. Lippincott Williams & Wilkins. 2nd edition. p. 98. ISBN 978-0-7817-3497-4. Google Book Search. Retrieved on 5 December 2010.
- Cater, D B; Adair, H M; Grove, C A (1966). "Effects of vasomotor drugs and 'mediators' of the inflammatory reaction upon the oxygen tension of tumours and tumour blood-flow". British Journal of Cancer 20 (3): 504–16. doi:10.1038/bjc.1966.62. PMC 2007997. PMID 4288476.
- B.D Cahurasia (2010). Human Anatomy: Regional & Applied (Dissection & Clinical) 5e (in 3 Vols.) Vol. 1: Upper Limb & Thorax With CD. New Delhi: CBS Publishers & Distributors. pp. 59, 133, 296. ISBN 978-81-239-1863-1.
- Guyton, Arthur C.; Hall, John Edward (2006). Textbook of Medical Physiology. Pennsylvania, United States: Elsevier Saunders. pp. 285, 1116. ISBN 0-7216-0240-1.
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