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WFDC5

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WFDC5
Identifiers
AliasesWFDC5, PRG5, WAP1, dJ211D12.5, WAP four-disulfide core domain 5
External IDsOMIM: 605161; MGI: 2384800; HomoloGene: 17072; GeneCards: WFDC5; OMA:WFDC5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_145652
NM_001395506

NM_145369

RefSeq (protein)

NP_663627

n/a

Location (UCSC)Chr 20: 45.11 – 45.12 MbChr 2: 164.02 – 164.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

WAP four-disulfide core domain protein 5 is a protein that in humans is encoded by the WFDC5 gene.[5][6][7]

This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. Most WFDC proteins contain only one WFDC domain, and this encoded protein contains two WFDC domains. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175121Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040154Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Clauss A, Lilja H, Lundwall A (Nov 2002). "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein". Biochem J. 368 (Pt 1): 233–42. doi:10.1042/BJ20020869. PMC 1222987. PMID 12206714.
  6. ^ Ranganathan S, Simpson KJ, Shaw DC, Nicholas KR (Mar 2000). "The whey acidic protein family: a new signature motif and three-dimensional structure by comparative modeling". J Mol Graph Model. 17 (2): 106–13, 134–6. doi:10.1016/S1093-3263(99)00023-6. PMID 10680116.
  7. ^ a b "Entrez Gene: WFDC5 WAP four-disulfide core domain 5".

Further reading

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