Wikipedia:USEP/Courses/JHU MolBio Ogg SP14/Group 81G

Initial Article Assessments from Cchandu1

Polysomy

This article contains a brief introduction and an example, however it can definitely be expanded upon. There is also only one reference provided. This article could definitely benefit from the use of an image or two. This article has been ranked as high-importance on the Molecular and Cellular Biology WikiProjects.

References:

1. . Polysomy. <http://medical-dictionary.thefreedictionary.com/polysomy>
2. . Moelans, Cathy B., Jorge S. Reis-Filho, and Paul J Van Diest. "Implications of Rarity of Chromosome 17 Polysomy in Breast Cancer." The Lancet Oncology 12.12 (2011): 1087-089. <http://www.sciencedirect.com.proxy3.library.jhu.edu/science/article/pii/S1470204511702340>
3. . Schildhaus, Hans-Ulrich, Lars Schroeder, Sabine Merkelbach-Bruse, Elke Binot, Reinhard Büttner, Walther Kuhn, and Christian Rudlowski. "Therapeutic Strategies in Male Breast Cancer: Clinical Implications of Chromosome 17 Gene Alterations and Molecular Subtypes." The Breast 22.6 (2013): 1066-071. <http://www.sciencedirect.com.proxy1.library.jhu.edu/science/article/pii/S0960977613002427>
4. . Higgins, Craig D., Anthony J. Swerdlow, Minouk J. Schoemaker, Alan F. Wright, and Patricia A. Jacobs. "Mortality and Cancer Incidence in Males with Y Polysomy in Britain: A Cohort Study." Human Genetics 121.6 (2007): 691-96. <http://search.proquest.com.proxy1.library.jhu.edu/docview/215506393?accountid=11752>
5. .Gardner, L. I. "Polysomy X Masquerading as Down's Syndrome: The Necessity of Being Earnest About Karyotype Analysis in the Diagnosis of Mongolism." Archives of Pediatrics and Adolescent Medicine 133.3 (1979): 253-54. <http://archpedi.jamanetwork.com.proxy1.library.jhu.edu/advancedSearchResults.aspx?y=&p=253&journalID=75&v=133>

Spermatocyte

Currently the article of spermatocyte barely contains a brief definition and two images that lack a description or tag from where it came from. This article is lacking any form of references and clearly could use work on it. There is a brief post on the talk page by someone further explaining the topic along with some suggested literature. It has been ranked as high-importance in both Genetics and Molecular and Cellular Biology WikiProjects.

References:

1. . Merriam-Webster Definition of Spermatocyte <http://www.merriam-webster.com/dictionary/spermatocyte>
2. . Graham, Johnson D. "The Sperm Nucleus: Chromatin, RNA, and the Nuclear Matrix." Reproduction 141 (2011): 21-36. The Journal of the Society for Reproduction and Fertility. doi: 10.1530/REP-10-0322. <http://www.reproduction-online.org/content/141/1/21.abstract#cited-by>.
3. . Mudrak, O. "Chromosome Architecture in the Decondensing Human Sperm Nucleus." Journal of Cell Science 118.19 (2005): 4541-550. doi=10.1242/​jcs.02581. <http://jcs.biologists.org/content/118/19/4541.abstract>

Initial Article Assessments from PaleoBioJackie

Molecular paleontology

This article is a stub-article but is claimed as part of seven different WikiProjects, due to its interdisciplinary nature. On the MCB Wikiproject it is rated as Mid-Importance. Right now, the article consists of five sentences and three references, making it sparse of much valuable information. The article could use sections explaining on Applications of Molecular Paleontology, Techniques of Molecular Paleontology, and a history of the subject. It would also benefit from some illustrations.

The talk page is currently blank. This article has a lot of potential, in that this field of study is currently rapidly expanding and there are several new articles on the subject in just the last five years.

References

1. Shapiro, B.; Hofreiter, M. (23 January 2014). "A Paleogenomic Perspective on Evolution and Gene Function: New Insights from Ancient DNA". Science 343 (6169): 1236573–1236573. doi:10.1126/science.1236573. Retrieved 26 February 2014.
2. Willerslev, E; Cooper, A (2005 Jan 7). "Ancient DNA.". Proceedings: Biological Sciences 272 (1558): 3–16. PMID 15875564.
3. Huynen, Leon; Millar, Craig D.; Lambert, David M. (August 2012). "Resurrecting ancient animal genomes: The extinct moa and more". BioEssays 34 (8): 661–669. doi:10.1002/bies.201200040.
4. Cooper, A; Wayne, R (1998 Feb). "New uses for old DNA.". Current opinion in biotechnology 9 (1): 49–53. PMID 9503587.
5. Green, RE; Krause, J; Ptak, SE; Briggs, AW; Ronan, MT; Simons, JF; Du, L; Egholm, M; Rothberg, JM; Paunovic, M; Pääbo, S (2006 Nov 16). "Analysis of one million base pairs of Neanderthal DNA.". Nature 444 (7117): 330–6. PMID 17108958.

Regulator Gene

This article is a Stub-class article rated of High-Importance to the MCB WikiProject. It currently consists of a brief summary of about 10 sentences on the subject, with three references. Understanding of this subject continues to develop at a rapid pace, although our understanding of Regulator Genes is not yet complete. This article would benefit from several more paragraphs, an expansion on existing information, and new illustrations. This article would be very interesting to pursue, although I think it will likely require more work than several other topics that are simpler and better understood.

References:

1. Yang, YI; Ahn, JH; Lee, KT; Shih, IM; Choi, JH (2014 Feb 24). "RSF1 is a positive regulator of NFkappaB-induced gene expression required for ovarian cancer chemoresistance.". Cancer research. PMID 24566868.
2. Ralston, JC; Badoud, F; Cattrysse, B; McNicholas, PD; Mutch, DM (2014 Feb 25). "Inhibition of stearoyl-CoA Desaturase-1 in Differentiating 3T3-L1 Pre-Adipocytes Up-regulates Elongase 6 and Down-regulates Genes Affecting Triacylglycerol Synthesis.". International journal of obesity (2005). PMID 24566853.
3. Rosenfeld, Melissa A.; Yoshimura, Kunihiko; Trapnell, Bruce C.; Yoneyama, Koichi; Rosenthal, Eugene R.; Dalemans, Wilfried; Fukayama, Masashi; Bargon, Joachim; Stier, Larue E.; Stratford-Perricaudet, Leslie; Perricaudet, Michel; Guggino, William B.; Pavirani, Andrea; Lecocq, Jean-Pierre; Crystal, Ronald G. (January 1992). "In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium". Cell 68 (1): 143–155. doi:10.1016/0092-8674(92)90213-V.

Article Selection Rationale

Molecular Paleontology

The field of Molecular Paleontology has grown tremendously in the last decade, allowing scientists to pursue evolutionary questions on a genetic level rather than relying on phenotypic variation alone. Sequencing of ancient DNA can yield substantial insights into evolutionary events, species' diasporas, population bottlenecks, and can easily quantify the level of relatedness between any two organisms. Using DNA sequencing to inspect ancestry and relatedness is considered much more reliable than other strategies, and this is especially true for species that no longer exist. Because of its interdisciplinary nature, Molecular paleontology has been claimed by 7 different WikiProjects, including as a mid-importance topic for the Molecular and Cellular Biology community.

This article topic is relevant to our Molecular Biology course, because research in this field relies considerably on biotechnology techniques we covered in class including PCR, gel electrophoresis, as well as a very thorough understanding of DNA and DNA screening and isolation techniques. Upon initial inspection, we will likely cover techniques for sequencing DNA preserved in fossils, techniques involved in isolating and amplifying the DNA, information about the history of the subject, information about the oldest organisms which have been sequenced and other notable organisms, environmental conditions needed to preserve DNA for long periods of time, and challenges inherent within this field.

The following are possible subsections to be added to the article:

1. . A history of the subject
2. . Techniques of Molecular Paleontology
3. . Applications of Molecular Paleontology
4. . See Also
5. . References
6. . Further Readings
7. . Links

PaleoBioJackie (talk) 21:59, 1 March 2014 (UTC) Cchandu1 (talk) 00:54, 5 March 2014 (UTC)

Unit 8 progress report

- Started a new article page for Molecular Paleontology (with the help of Klortho).

- All of our contributions were prose.

Cchandu1 (talk) 02:37, 26 March 2014 (UTC)

Unit 10 progress report

-Added content, photos, WikiLinks. Incorporated our reviewers suggestions(in progress). Added article to categories. -Began building a chronological timeline for Molecular Paleontology. This will be published after completion. PaleoBioJackie (talk) 00:03, 9 April 2014 (UTC)

1. Added additional Wikilinks
2. Added content to history section, as well as timeline.
3. Used reviewers suggestions.

Cchandu1 (talk) 03:55, 9 April 2014 (UTC)

Unit 12 progress report

1. Incorporated reviewers suggestions and corrections.
2. Completed Research and Technology section, as well as added images
3. Corrected introduction and references
4. Restructured article
5. Added to History, Timeline, and Applications
6. Attained copyright permissions for a new image

Cchandu1 (talk) 21:25, 22 April 2014 (UTC) PaleoBioJackie (talk) 00:11, 23 April 2014 (UTC)

Unit 14 progress report

1. Added page to Paleontology template
2. Formatted overall article
3. Most of our contributions were prose
4. Added alternative text to images
5. Added links from other pages
6. Added formatting to avoid sections overlapping with pictures
7. Re-read entire page and added missing Wiki-links
8. Added main article links

Notable contributors included Klortho and Graeme, who really helped provide many great points to develop the page further. Another contributor who really helped was Neelix, who provided overall really good advice on how to make our page look better, as well as different formatting options that we previously had not considered.

PaleoBioJackie (talk) 19:08, 6 May 2014 (UTC) Cchandu1 (talk) 21:58, 6 May 2014 (UTC)