Young-Tae Chang

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Young-Tae Chang
Native name 장영태
Born Pusan, South Korea
Doctoral advisor Prof. Sung-Kee Chung
Other academic advisors Prof. Peter G. Schultz

Young-Tae Chang is a professor of chemistry at Pohang University of Science and Technology (POSTECH), Korea.

Young-Tae Chang was born in Pusan, South Korea in 1968. He obtained a Bachelor of Science degree in chemistry from POSTECH, working on the divergent synthesis of all regioisomers of myo-inositol phosphates, under guide of Prof. Sung-Kee Chung. He then engaged in postdoctoral research in the laboratory of Prof. Peter G. Schultz. in 2000. He was appointed assistant professor at New York University (NYU) and promoted to associated professor in 2005. In September 2007, he moved to the National University of Singapore and the Singapore Bioimaging Consortium at Biopolis. From 2017, he is a Full Professor in the Department of Chemistry, POSTECH and head of the Laboratory of Bioimaging Probe Development at SBIC. He pioneered diversity-oriented fluorescence library approach (DOFLA),[1][2] and developed embryonic stem cell probe CDy1,[3] neuronal stem cell probe CDr3,[4] and neron specific probe, NeuO.[5] He also developed a method for background-free live cell imaging with tamed fluorescent probe.[6] He is an editorial board member of MedChemComm and RSC Advances, Royal Society of Chemistry, and American Journal of Nuclear Medicine and Molecular Imaging. He has published more than 300 scientific papers and 3 books and has filed more than 50 patents so far. He has received numerous awards including NSF Career award in 2005 and NUS Young Investigator Award in 2007.


  1. ^ VENDREL, MARC; Duanting Zhai; Jun Cheng Er; Young-Tae Chang (2012). "Combinatorial strategies in fluorescent probe development". Chem. Rev. 112 (8): 4391–4420. PMID 22616565. doi:10.1021/cr200355j. 
  2. ^ Nam-Young Kang, Hyung-Ho Ha, Seong-Wook Yun, Young Hyun Yu, Young-Tae Chang (2011). "Diversity-driven chemical probe development for biomolecules: beyond hypothesis-driven approach". Chem. Soc. Rev. 40 (7): 3613–3626. PMID 21526237. doi:10.1039/C0CS00172D. 
  3. ^ Chang-Nim Im, Nam-Young Kang, Hyung-Ho Ha, Xuezhi Bi, Jae Jung Lee, Sung-Jin Park,Sang Yeon Lee, Marc Vendrell, Yun Kyung Kim, Jun-Seok Lee, Jun Li, Young-Hoon Ahn, Bo Feng, Huck-Hui Ng, Seong-Wook Yun, Young-Tae Chang (2010). "A Fluorescent Rosamine Compound Selectively Stains Pluripotent Stem Cells". Angew. Chem. Int. Ed. 49 (41): 7497–7500. PMID 20814992. doi:10.1002/anie.201002463. 
  4. ^ Seong-Wook Yun, Cheryl Leong, Duanting Zhai, Yee Ling Tan, Linda Limd, Xuezhi Bi, Jae-Jung Lee, Han Jo Kim, Nam-Young Kang, Shin Hui Ng, Lawrence W. Stanton, Young-Tae Chang (2012). "Neural stem cell specific fluorescent chemical probe binding to FABP7". PNAS. 109 (26): 10214–10217. PMC 3387064Freely accessible. PMID 22689954. doi:10.1073/pnas.1200817109. 
  5. ^ Er, Jun Cheng; Leong, Cheryl; Teoh, Chai Lean; Yuan, Qiang; Merchant, Paolomi; Dunn, Matthew; Sulzer, David; Sames, Dalibor; Bhinge, Akshay (2015-02-16). "NeuO: a fluorescent chemical probe for live neuron labeling". Angewandte Chemie International Edition in English. 54 (8): 2442–2446. ISSN 1521-3773. PMID 25565332. doi:10.1002/anie.201408614. 
  6. ^ Alamudi, Samira Husen; Satapathy, Rudrakanta; Kim, Jihyo; Su, Dongdong; Ren, Haiyan; Das, Rajkumar; Hu, Lingna; Alvarado-Martínez, Enrique; Lee, Jung Yeol (2016-01-01). "Development of background-free tame fluorescent probes for intracellular live cell imaging". Nature Communications. 7: 11964. ISSN 2041-1723. PMC 4915154Freely accessible. PMID 27321135. doi:10.1038/ncomms11964. 

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