ZDHHC2

ZDHHC2
Identifiers
Aliases	ZDHHC2, DHHC2, ZNF372, zinc finger DHHC-type containing 2, zinc finger DHHC-type palmitoyltransferase 2
External IDs	MGI: 1923452; HomoloGene: 81667; GeneCards: ZDHHC2; OMA:ZDHHC2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	17,224,799 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	40,963,309 bp
RNA expression pattern
	Top expressed in
	sperm; ; retinal pigment epithelium; ; pancreatic epithelial cell; ; tibialis anterior muscle; ; mucosa of ileum; ; Skeletal muscle tissue of rectus abdominis; ; biceps brachii; ; spinal ganglia; ; renal medulla; ; deltoid muscle;
	Top expressed in
	cranial nervi; ; trigeminal nerve; ; islet of Langerhans; ; barrel cortex; ; lumbar spinal ganglion; ; autonomic nerve plexus; ; parasympathetic nervous system; ; ventromedial nucleus; ; retinal pigment epithelium; ; trigeminal ganglion;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein-cysteine S-palmitoyltransferase activity; transferase activity; acyltransferase activity; palmitoyltransferase activity;
Cellular component	integral component of membrane; plasma membrane; Golgi apparatus; recycling endosome membrane; integral component of plasma membrane; endoplasmic reticulum; membrane;
Biological process	protein palmitoylation; protein targeting to membrane; peptidyl-L-cysteine S-palmitoylation;
	Sources:Amigo / QuickGO
Orthologs
	51201
	70546
	ENSG00000104219
	ENSMUSG00000039470
	Q9UIJ5
	P59267
	NM_016353; NM_001362988; NM_001362989
	NM_178395; NM_001357249
	NP_057437; NP_001349917; NP_001349918
	NP_848482; NP_001344178
	Wikidata
View/Edit Human	View/Edit Mouse

zinc finger, also known as ZDHHC2, is a human gene.^[5]

zinc finger, DHHC-type containing 2^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104219 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039470 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: zinc finger".

Zhang J, Planey SL, Ceballos C, et al. (2008). "Identification of CKAP4/p63 as a major substrate of the palmitoyl acyltransferase DHHC2, a putative tumor suppressor, using a novel proteomics method". Mol. Cell Proteomics. 7 (7): 1378–88. doi:10.1074/mcp.M800069-MCP200. PMC 2493380. PMID 18296695.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Li B, Cong F, Tan CP, et al. (2002). "Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has pro-apoptotic activity". J. Biol. Chem. 277 (32): 28870–6. doi:10.1074/jbc.M202388200. PMID 12021275.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Rose JE, Behm FM, Drgon T, et al. "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Oyama T, Miyoshi Y, Koyama K, et al. (2000). "Isolation of a novel gene on 8p21.3-22 whose expression is reduced significantly in human colorectal cancers with liver metastasis". Genes Chromosomes Cancer. 29 (1): 9–15. doi:10.1002/1098-2264(2000)9999:9999<::AID-GCC1001>3.0.CO;2-#. PMID 10918388.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ravasi T, Suzuki H, Cannistraci CV, et al. (2010). "An atlas of combinatorial transcriptional regulation in mouse and man". Cell. 140 (5): 744–52. doi:10.1016/j.cell.2010.01.044. PMC 2836267. PMID 20211142.
Planey SL, Keay SK, Zhang CO, Zacharias DA (2009). "Palmitoylation of cytoskeleton associated protein 4 by DHHC2 regulates antiproliferative factor-mediated signaling". Mol. Biol. Cell. 20 (5): 1454–63. doi:10.1091/mbc.E08-08-0849. PMC 2649263. PMID 19144824.
Sharma C, Yang XH, Hemler ME (2008). "DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151". Mol. Biol. Cell. 19 (8): 3415–25. doi:10.1091/mbc.E07-11-1164. PMC 2488315. PMID 18508921.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104219 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039470 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: zinc finger".

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[2]

[3]

[4]

[5]

References

Further reading