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ZPM may refer to:

  • Mixtepec Zapotec (ISO 639-3 code: zpm), an Oto-Manguean language of Oaxaca, Mexico
  • Zero Point Module, a fictional technology from the Stargate franchise
  • Zero-propellant maneuver, an optimal attitude trajectory used to perform spacecraft rotational control without the need to use thrusters
  • Zyvex Technologies (previously Zyvex Performance Materials), a molecular engineering company headquartered in Columbus, Ohio