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Ze339 brand herbal extracts are taken from the leaves of a unique variety (Petzell) of the butterbur (Petasites hybridus) plant. Petzell is grown on GAP-managed farms in Europe.

Petzell plants prepared for planting
Field of Petasites hybridus growing on a Swiss farm


In Switzerland, South Korea and Brazil, tablets containing Ze339 brand herbal extracts are marketed under the brand name Tesalin. Ze339 is marketed in the US as Zarbee's Naturals Seasonal Relief.

Seasonal allergic rhinitis[edit]

Ze339 is indicated for seasonal allergic rhinitis (hay fever). The ingredient has been evaluated in placebo-controlled, double-blind clinical studies. Ze339 was shown to be as effective as the antihistamines cetirizine and fexofenadine.[1][2] Against desloratadine, an improved version of loratadine, Ze339 had better efficacy in relieving congestion and other allergy symptoms.[3][4] In these studies, Ze339 was shown to be less sedating than cetirizine and fexofenadine.[1][2]


Ze339 brand extract is not an antihistamine and represents a symptomatic treatment with very different properties.[3] In-vitro studies show that petasins in Ze339 brand extract inhibit leukotriene biosynthesis and block degranulation in activated mast cells and eosinophils.[5][6]


  1. ^ a b Schapowal, A; Petasites Study, Group (January 19, 2002). "Randomised controlled trial of butterbur and cetirizine for treating seasonal allergic rhinitis". British Medical Journal. 324 (7330): 144–6. doi:10.1136/bmj.324.7330.144. PMC 64514Freely accessible. PMID 11799030. 
  2. ^ a b Schapowal, A; Study, Group (1 June 2005). "Treating intermittent allergic rhinitis: a prospective, randomized, placebo and antihistamine-controlled study of Butterbur extract Ze 339". Phytotherapy Research. 19 (6): 530–537. doi:10.1002/ptr.1705. PMID 16114089. Retrieved 24 April 2013. 
  3. ^ a b Dumitru, Alina F.; Shamji, Mohamed; Wagenmann, Martin; Hindersin, Simone; Scheckenbach, Kathrin; Greve, Jens; Klenzner, Thomas; Hess, Lorenzo; Nebel, Sabine; Zimmermann, Christian; Zahner, Catherine; Schmidt-Weber, Carsten B.; Chaker, Adam M. "Petasol butenoate complex (Ze 339) relieves allergic rhinitis–induced nasal obstruction more effectively than desloratadine". Journal of Allergy and Clinical Immunology. 127 (6): 1515–1521.e6. doi:10.1016/j.jaci.2011.02.045. PMID 21489609. 
  4. ^ "www.jacionline.org/article/S0091-6749%2811%2900426-X/journalimage?loc=gr3&src=fig&free=yes&source=imageTab". 
  5. ^ Thomet, O. A. R.; Wiesmann, U. N.; Blaser, K.; Simon, H.-U. (1 August 2001). "Differential inhibition of inflammatory effector functions by petasin, isopetasin and neopetasin in human eosinophils". Clinical & Experimental Allergy. 31 (8): 1310–1320. doi:10.1046/j.1365-2222.2001.01158.x. 
  6. ^ Thomet, Olivier A.R; Wiesmann, Ulrich N; Schapowal, Andreas; Bizer, Christian; Simon, Hans-Uwe. "Role of petasin in the potential anti-inflammatory activity of a plant extract of petasites hybridus". Biochemical Pharmacology. 61 (8): 1041–1047. doi:10.1016/S0006-2952(01)00552-4. PMID 11286996.