Desloratadine

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Desloratadine
Desloratadine.svg
Desloratadine2.png
Clinical data
Trade names Clarinex
AHFS/Drugs.com Monograph
MedlinePlus a602002
License data
Pregnancy
category
  • AU: B1
  • US: C (Risk not ruled out)
Routes of
administration
Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability Rapidly absorbed
Protein binding 85%
Metabolism Hepatic
Biological half-life 27 hours
Excretion 40% as conjugated metabolites into urine
Similar amount into the feces
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.166.554
Chemical and physical data
Formula C19H19ClN2
Molar mass 310.82
3D model (JSmol)
  (verify)

Desloratadine is a tricyclic H1-antihistamine that is used to treat allergies. It is an active metabolite of loratadine.

Use[edit]

Desloratadine is used to treat allergic rhinitis and nasal congestion.[1] It is the major metabolite of loratadine and the two drugs are similar in safety and effectiveness.[1] Desloratadine is available in many dosage forms and under many trade names worldwide.[2]

An emerging indication for desloratadine is in the treatment of acne, as an inexpensive adjuvant to isotretinoin and possibly as maintenance therapy or monotherapy.[3][4]

Side effects[edit]

Most common side-effects are fatigue, dry mouth, headache, vomiting and gastrointestinal disturbances.[1]

Mechanism of action[edit]

Desloratadine is a selective H1-antihistamine which functions as an inverse agonist at the histamine H1 receptor;[5]

It is also an antagonist at all subtypes of the muscarinic acetylcholine receptors.[citation needed]

It exhibits only peripheral activity since it does not readily cross the blood-brain barrier; hence, it does not cause drowsiness because it does not readily enter the central nervous system.[6]

It has a long-lasting effect and is effective in moderate and low doses.

See also[edit]

References[edit]