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Acylpyruvate hydrolase

From Wikipedia, the free encyclopedia
acylpyruvate hydrolase
Identifiers
EC no.3.7.1.5
CAS no.54004-67-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins

In enzymology, an acylpyruvate hydrolase (EC 3.7.1.5) is an enzyme that catalyzes the chemical reaction

a 3-acylpyruvate + H2O a carboxylate + pyruvate

Thus, the two substrates of this enzyme are 3-acylpyruvate and water, whereas its two products are carboxylate and pyruvate.

This enzyme belongs to the family of hydrolases, specifically those acting on carbon-carbon bonds in ketonic substances. The systematic name of this enzyme class is 3-acylpyruvate acylhydrolase. This enzyme participates in tyrosine metabolism.

References

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  • Watson GK, Houghton C, Cain RB (1974). "Microbial metabolism of the pyridine ring. The metabolism of pyridine-3,4-diol (3,4-dihydroxypyridine) by Agrobacterium sp". Biochem. J. 140 (2): 277–92. PMC 1167999. PMID 4375963.