Non-ossifying fibroma: Difference between revisions
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Diagnosis is by [[X-ray]] or [[MRI]], usually when investigating a person for something else.<ref name="Santini2"/> [[Medical imaging]] typically shows a well |
Diagnosis is by [[X-ray]] or [[MRI]], usually when investigating a person for something else.<ref name="Santini2"/> [[Medical imaging]] typically shows a well defined radiolucent lesion, with a distinct multilocular appearance, sometimes looking like bubbles.<ref name="Santini2"/> It is usually around 1-2cm in size, but be as large as 7cm.<ref name="Paulos2021">{{cite book |last1=Paulos |first1=Jaime |title=Bone Tumors: Diagnosis and Therapy Today |date=2021 |publisher=Springer |isbn=978-1-4471-7501-8 |pages=139–139 |url=https://link.springer.com/chapter/10.1007/978-1-4471-7501-8_22#citeas |language=en |chapter=Non Ossifying Fibroma}}</ref> They consist of foci consist of [[collagen]] rich [[connective tissue]], [[fibroblast]]s, [[histiocyte]]s and [[osteoclast]]s.<ref name="Santini2"/> Usually no treatment is required.<ref name=WHOblue2020/> Surgical curettage and bone grafting may be required if it is large.<ref name="Paulos2021"/> |
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Revision as of 03:23, 3 August 2021
| Non-ossifying fibroma | |
|---|---|
| Other names | Fibroxanthoma |
 | |
| X-ray of nonossifying fibroma of distal tibia. | |
| Specialty | Rheumatology  |
A non-ossifying fibroma (NOF) is a benign bone tumor of the osteoclastic giant cell-rich tumor type.[1] It generally occurs in the metaphysis of long bones in children and adolescents.[2] Typically, there are no symptoms unless there is a fracture.[2] It can occur as part of a syndrome such as when multiple non-ossifying fibromas occur in neurofibromatosis, or Jaffe-Campanacci syndrome in combination with cafe-au-lait spots, mental retardation, hypogonadism, eye and cardiovascular abnormalities.[2]
Diagnosis is by X-ray or MRI, usually when investigating a person for something else.[2] Medical imaging typically shows a well defined radiolucent lesion, with a distinct multilocular appearance, sometimes looking like bubbles.[2] It is usually around 1-2cm in size, but be as large as 7cm.[3] They consist of foci consist of collagen rich connective tissue, fibroblasts, histiocytes and osteoclasts.[2] Usually no treatment is required.[1] Surgical curettage and bone grafting may be required if it is large.[3]
It is found in 30-40% of children and adolescents, but rare in adults as most have resolved by this time.[2] They do not become malignant.[2] It affects twice as many males as females.[2] A NOF was identified on the mandible of Qafzeh 9, an early anatomically modern human dated to 90–100 000 yrs B.P.[4]
Additional images
See also
References
- ^ a b WHO Classification of Tumours Editorial Board, ed. (2020). "Non-ossifying fibroma". Soft Tissue and Bone Tumours: WHO Classification of Tumours. Vol. 3 (5th ed.). Lyon (France): International Agency for Research on Cancer. pp. 447–448. ISBN 978-92-832-4503-2.
- ^ a b c d e f g h i Murali, Sundaram; Ilaslan, Hakan; Holden, Darlene M. (2015). "2. An imaging approach to bone tumors". In Santini-Araujo, Eduardo; Kalil, Ricardo K.; Bertoni, Franco; Park, Yong-Koo (eds.). Tumors and Tumor-Like Lesions of Bone: For Surgical Pathologists, Orthopedic Surgeons and Radiologists. Springer. p. 15. ISBN 978-1-4471-6577-4.
- ^ a b Paulos, Jaime (2021). "Non Ossifying Fibroma". Bone Tumors: Diagnosis and Therapy Today. Springer. pp. 139–139. ISBN 978-1-4471-7501-8.
- ^ Coutinho Nogueira D, Dutour O, Coqueugniot H, Tillier A.-m., (2019) Qafzeh 9 mandible (ca 90–100 kyrs BP, Israel) revisited : μ-CT and 3D reveal new pathological conditions, International Journal of Paleopathology, Vol 26, pp.104-110, https://doi.org/10.1016/j.ijpp.2019.06.002
External links
Media related to Nonossifying fibroma at Wikimedia Commons- Wheeless' Textbook of Orthopaedics: Nonossifying Fibroma
