Hypertrophic pulmonary osteoarthropathy

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Hypertrophic pulmonary osteoarthropathy
Bonescan of a patient with hypertrophic pulmonary osteoarthropathy
Classification and external resources
ICD-10 M89.4
ICD-9 731.2
DiseasesDB 6388

Hypertrophic pulmonary osteoarthropathy (or Bamberger-Marie syndrome)[1] is a medical condition combining clubbing and periostitis of the small hand joints, especially the distal interphalangeal joints. Distal expansion of the long bones as well as painful, swollen joints[2] and synovial villous proliferation are often seen. The condition may occur alone (primary), or it may be secondary to diseases like lung cancer. It is especially associated with non-small cell lung carcinoma. These patients often get clubbing and increased bone deposition on long bones. Their presenting symptoms are sometimes only clubbing and painful ankles.

It is also known as "osteoarthropathia hypertrophicans".[3]


It is named for Eugen von Bamberger and Pierre Marie.[4][5][6]

See also[edit]


  1. ^ Armstrong DJ, McCausland EM, Wright GD (February 2007). "Hypertrophic pulmonary osteoarthropathy (HPOA) (Pierre Marie-Bamberger syndrome): two cases presenting as acute inflammatory arthritis. Description and review of the literature". Rheumatol. Int. 27 (4): 399–402. doi:10.1007/s00296-006-0224-2. PMID 17006703. 
  2. ^ Goldman, Lee (2011). Goldman's Cecil Medicine (24th ed.). Philadelphia: Elsevier Saunders. p. 1196. ISBN 1437727883. 
  3. ^ Deller A, Heuer B, Wiedeck H (December 1998). "Is myositis ossificans following ARDS a complication of prone-dependency or is it osteoarthropathia hypertrophicans (Bamberger-Marie syndrome)?". Intensive Care Med 24 (12): 1345–6. doi:10.1007/s001340050776. PMID 9885895. Archived from the original on 1999-08-23. 
  4. ^ synd/1756 at Who Named It?
  5. ^ von Bamberger E (1889). "Veränderungen der Röhrenknochen bei Bronchiektasie". Wiener klinische Wochenschrift 2: 226. 
  6. ^ Marie P (1890). "De l’osteo-arthropathie hypertrophiante pneumique". Rév Med, Paris 10: 1–36.