Jump to content

Giant-cell fibroblastoma: Difference between revisions

Add links
From Wikipedia, the free encyclopedia
Browse history interactively
← Previous editNext edit →
Content deleted Content added
VisualWikitext
m Updating with the World Health Organizations 2020 classification of these tumors.
Updating and expanding article
Line 1: Line 1:
{{Infobox medical condition (new)
{{Infobox medical condition (new)
| name = <!--{{PAGENAME}} by default-->
| name = Giant cell fibroblastoma
| synonym =
| synonym =
| image = <!-- Just the filename without File: or |thumb, etc. -->
| image = <!-- Just the filename without File: or |thumb, etc. -->
Line 7: Line 7:
| caption =
| caption =
| pronounce =
| pronounce =
| specialty = oncology
| specialty = [[Pediatrics]], [[Dermatology]], [[Pathology]]
| symptoms =
| symptoms = Painless mass in the [[dermis]]
| complications =
| complications =
| onset =
| onset = Pediatric population
| duration =
| duration =
| types =
| types =
| causes =
| causes = Thought to be the formation of a ''COL1A1-PDGFB'' [[fusion gene]]
| risks =
| risks =
| diagnosis =
| diagnosis =
| differential =
| differential =
| prevention =
| prevention =
| treatment =
| treatment = Surgical excision
| medication =
| medication =
| prognosis =
| prognosis = Good
| frequency =
| frequency = Rare
| deaths =
| deaths =
}}
}}

'''Giant-cell fibroblastoma''' is a rare type of [[soft-tissue]] [[tumor]] [[marked]] by [[painless]] [[Nodule (medicine)|nodules]] in the [[dermis]] (the inner layer of the two main layers of tissue that make up the [[skin]]) and [[Subcutaneous tissue|subcutaneous]] (beneath the skin) tissue. These tumors may come back after [[surgery]], but they do not spread to other parts of the body. They occur mostly in [[boy]]s and are related to [[dermatofibrosarcoma protuberans]].<ref>{{cite book|last1=Cerio|first1=R.|title=Dermatopathology|date=2012|publisher=Springer Science & Business Media|isbn=9783642595523|url=https://books.google.com/books?id=yoVHBAAAQBAJ&q=Giant-cell+fibroblastoma+boy|accessdate=13 November 2017|language=en}}</ref> The World Health Organization (2020) classified these tumors as a specific type of tumors in the category of intermediate (locally aggressive) [[fibroblastic and myofibroblastic tumors]].<ref name="pmid33179614">{{cite journal | vauthors = Sbaraglia M, Bellan E, Dei Tos AP | title = The 2020 WHO Classification of Soft Tissue Tumours: news and perspectives | journal = Pathologica | volume = 113 | issue = 2 | pages = 70–84 | date = April 2021 | pmid = 33179614 | pmc = 8167394 | doi = 10.32074/1591-951X-213 | url = }}</ref>
'''Giant cell fibroblastoma''' (GCF) is a rare type of [[soft-tissue]] [[tumor]] [[marked]] by [[painless]] [[Nodule (medicine)|nodules]] in the [[dermis]] (the inner layer of the two main layers of tissue that make up the [[skin]]) and [[Subcutaneous tissue|subcutaneous]] (beneath the skin) tissue. These tumors may come back after [[surgery]], but they do not spread to other parts of the body. They occur mostly in [[boy]]s.<ref>{{cite book|last1=Cerio|first1=R.|title=Dermatopathology|date=2012|publisher=Springer Science & Business Media|isbn=9783642595523|url=https://books.google.com/books?id=yoVHBAAAQBAJ&q=Giant-cell+fibroblastoma+boy|accessdate=13 November 2017|language=en}}</ref> GCF tumor tissues consist of bland spindle-shaped or stellate-shaped cells interspersed among [[multinucleated giant cells]].<ref name="pmid32764969">{{cite journal | vauthors = Dong SS, Wang N, Yang CP, Zhang GC, Liang WH, Zhao J, Qi Y | title = Giant Cell-Rich Solitary Fibrous Tumor in the Nasopharynx: Case Report and Literature Review | journal = OncoTargets and Therapy | volume = 13 | issue = | pages = 6819–6826 | date = 2020 | pmid = 32764969 | pmc = 7367732 | doi = 10.2147/OTT.S252696 | url = }}</ref>

GCF tumors are closely related to [[dermatofibrosarcoma protuberans]] (DFSP) and [[Dermatofibrosarcoma protuberans#Fibrosarcomatous DFSP (DFSP-FS)|dermatofibrosarcoma protuberans, fibrosarcomatous]] (DFSP-FS) (also termed fibrosarcomatous dermatofibrosarcoma protuberans) tumors.<ref name="pmid31950474">{{cite journal | vauthors = Baranov E, Hornick JL | title = Soft Tissue Special Issue: Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck | journal = Head and Neck Pathology | volume = 14 | issue = 1 | pages = 43–58 | date = March 2020 | pmid = 31950474 | pmc = 7021862 | doi = 10.1007/s12105-019-01104-3 | url = }}</ref> The World Health Organization (2020) classified these three tumors as different tumors in the category of [[fibroblastic and myofibroblastic tumors]] with GCF and DFSP sub-classified as benign but aggressive tumors and DFSP-FS subclassified as a rarely metastasizing tumor.<ref name="pmid33179614">{{cite journal | vauthors = Sbaraglia M, Bellan E, Dei Tos AP | title = The 2020 WHO Classification of Soft Tissue Tumours: news and perspectives | journal = Pathologica | volume = 113 | issue = 2 | pages = 70–84 | date = April 2021 | pmid = 33179614 | pmc = 8167394 | doi = 10.32074/1591-951X-213 | url = }}</ref> However, The three tumor types may contain areas that have a microscopic [[histopathological]] appearance similar to one of the other types.<ref name="pmid32163628">{{cite journal | vauthors = Braswell DS, Ayoubi N, Motaparthi K, Walker A | title = Dermatofibrosarcoma protuberans with features of giant cell fibroblastoma in an adult | journal = Journal of Cutaneous Pathology | volume = 47 | issue = 4 | pages = 317–320 | date = April 2020 | pmid = 32163628 | doi = 10.1111/cup.13601 | url = }}</ref> Furthermore, following their surgical resection GCF tumors may recur as DFSP tumors and vice versa and DFSP tumors may recur as DFSP-FS tumors. CGF, DFSP, and DFSP-FS have been regarded as an increasingly aggressive spectrum of related tumors.<ref name="pmid17349565">{{cite journal | vauthors = Jha P, Moosavi C, Fanburg-Smith JC | title = Giant cell fibroblastoma: an update and addition of 86 new cases from the Armed Forces Institute of Pathology, in honor of Dr. Franz M. Enzinger | journal = Annals of Diagnostic Pathology | volume = 11 | issue = 2 | pages = 81–8 | date = April 2007 | pmid = 17349565 | doi = 10.1016/j.anndiagpath.2006.12.010 | url = }}</ref>

Giant cell fibroblastoma tumors are typically treated by surgical resection but have a very high rate of recurrence at the sites of their resection, particularly in cases where all of the tumor has not been removed. Accordingly, wide, complete tumor resections are the recommended treatment for them.<ref name="pmid17349565"/>

==Presentation==
As found in one study of 86 individuals, GCF commonly present as single tumors in children less than 10 years old (62% of cases), 10-40 year old individuals (26% of cases), and adults greater that 40 years (12% of cases) (overall median age: 6 years).<ref name="pmid17349565"/> There is a strong predominance of males in the reported cases of GCF.<ref name="pmid31950474"/><ref name="pmid12502925">{{cite journal | vauthors = Terrier-Lacombe MJ, Guillou L, Maire G, Terrier P, Vince DR, de Saint Aubain Somerhausen N, Collin F, Pedeutour F, Coindre JM | title = Dermatofibrosarcoma protuberans, giant cell fibroblastoma, and hybrid lesions in children: clinicopathologic comparative analysis of 28 cases with molecular data--a study from the French Federation of Cancer Centers Sarcoma Group | journal = The American Journal of Surgical Pathology | volume = 27 | issue = 1 | pages = 27–39 | date = January 2003 | pmid = 12502925 | doi = 10.1097/00000478-200301000-00004 | url = }}</ref> The tumors are slow-growing, painless, often protuberant, multinodular or [[Polyp (medicine)|polyp-like]] dermal and subcutaneous tumors masses or plaques (i.e. a lesion that is greater in its diameter than in its depth) that commonly occur on the trunk, proximal extremities, or rarely the head and neck areas.<ref name="pmid31950474"/>

==Pathology==
As defined by microscopic [[histopathology]] analyses, GCF tumors consist of a few spindle- and/or stellate-shaped cells in a [[Sclerosis (medicine)|sclerotic]] (i.e. [[collagen]] fiber-rich) background<ref name="pmid32516921">{{cite journal | vauthors = Hao X, Billings SD, Wu F, Stultz TW, Procop GW, Mirkin G, Vidimos AT | title = Dermatofibrosarcoma Protuberans: Update on the Diagnosis and Treatment | journal = Journal of Clinical Medicine | volume = 9 | issue = 6 | pages = | date = June 2020 | pmid = 32516921 | pmc = 7355835 | doi = 10.3390/jcm9061752 | url = }}</ref> with distinctive dilated blood vessel-like spaces lined by floret-shaped (i.e. small flower-shaped) multinuclear giant cells.<ref name="pmid31950474"/> The giant cells vary in size and shape with their [[nuclei]] often lined-up in wreath-like or lobular formations.<ref name="pmid32764969"/> The tumors may infiltrate into and through nearby subcutaneous fat tissue,<ref name="pmid32764969"/> commonly have intralesional hemorrhages and distinctive perivascular onionskin-like [[lymphocytes]],<ref name="pmid17349565"/> and occasionally contain nodules of smooth muscle-like cells. Some GCF tumors have hybrid characteristics with areas resembling DFSP (e.g. immature-appearing<ref name="pmid12502925"/> spindle- and/or stellate-shaped cells with abnormally dark nuclei arranged in a monotonous cartwheel or whorled pattern<ref name="pmid17349565"/>). These hybrid lesions typical have pure GCF-like areas, pure DFSP-like areas, and mixed areas with a gradual or abrupt transition from one to the other.<ref name="pmid12502925"/> Surgically removed GCF may recur as a DFSP (and vice versa).<ref name="pmid32764969"/><ref name="pmid17349565"/> (DFSP-FS tumors consist of rapidly growing bundles of spindle- and/or stellate-shaped cells with [[vesicle]]-containing, abnormally shaped nuclei.<ref name="pmid32764969"/>)

[[Immunohistochemistry]] analyses indicate that the tumor cells in GCF express [[CD34]] and [[vimentin]] proteins but not [[MUC1|epithelial membrane antigen]] (also termed MUC1),<ref name="pmid12502925"/> [[SMA]], [[desmin]], [[HMB-45]], [[keratin]], [[S100 protein|S100]],<ref name="pmid17349565"/> or [[MLANA]] (also termed Melan-A) proteins.<ref name="pmid32163628"/>

==Chromosome and gene abnormalities==
Cases of GCF consistently contain tumor cells that express a ''COL1A1-PDGFB'' [[fusion gene]], i.e. a hybrid gene formed by a [[chromosomal translocation]] which mergers two previously independent genes. The ''[[COL1A1]]'' gene, which directs production of collagen, type I, alpha 1 protein, is normally located in [[Karyotype#Types of banding|band]] 21.33 on the [[Locus (genetics)#Nomenclature|long (or "q") arm]] of [[chromosome 17]].<ref>https://www.ncbi.nlm.nih.gov/gene/1277</ref> The ''[[PDGFB]]'' gene, which directs production of platelet-derived growth factor subunit B (PDGFβ), is normally located in band 13.1 on the q arm of [[chromosome 22]]. This translocation is typically balanced, i.e. involving an even exchange of material with no genetic information gained or lost and, ideally, resulting in the formation of a fusion gene which directs production of a fully functional protein. DFSP tumors cells also express a ''COL1A1-PDGFB'' fusion gene, but this fusion gene typically results from the formation of small supernumerary [[ring chromosome]], i.e. an extra ring-shaped chromosome that contains a merger between the ''COL1A1'' and ''PDGFB'' genes. Hybrid GCF-DFSP tumors typically have more copies of the ''COL1A1-PDGFB'' fusion gene in DFSP areas compared to GCF areas and GCF tumors progressing to hybrid GCF-DFSP, GCF progressing to DFSP, and DFSP progressing to DFSP-FS tumors tend to show step-wise increases in the total numbers of these fusion genes that they express.<ref name="pmid31950474"/>

Either form of the ''COL1A1-PDGFB'' [[fusion gene]] leads to the overexpression of fully active PDGFβ proteins and thereby the continuous activation of the their target, the [[PDGF receptor|PDGF receptor β]], along with this receptor β [[protein-tyrosine kinase]] activity. The continuously active protein-tyrosine kinase stimulates [[mitogen-activated protein kinase]], [[PI3K/AKT/mTOR pathway|PI3K/AKT/mTOR]], and other [[cell signaling]] pathways which promote the growth, proliferation, and abnormally prolonged survival of their parent cells. It is suggested that these events underlie the development and progression of GCF, GCF-DFSP, DFSP, and DFSP-FS tumors.<ref name="pmid32516921"/>

==Diagnosis==
The diagnosis of GCF depends on its presentation as a dermal tumor that has a characteristic histology consisting of spindle- and/or stellate-shaped CD34 protein-expressing cells, distinctive dilated blood vessel-like spaces lined by floret-shaped multinuclear giant cells, and/or distinctive perivascular onionskin-like [[lymphocytes]] and/or intralesional hemorrhages<ref name="pmid17349565"/> in a collagen fiber-rich background.<ref name="pmid17349565"//><ref name="pmid12502925"/> Presence of tumor cells containing a ''COL1A1-PDGFB'' fusion gene, particularly if it is due to a chromosomal translocation rather than an extra supernumerary chromosome, strongly supports the diagnosis of GCF.<ref name="pmid31950474"/><ref name="pmid12502925"/> GSF may have areas with the pathologic and chromosomal findings of DFSP. GCF and these "hybrid" tumors, when surgically resected, often recur and may recur as DFSP tumors.<ref name="pmid32163628"/>

==Treatment and prognosis==
Surgical excision with wide surgical margins to ensure the removal of all tumor tissue is the treatment of choice for GCF tumors<ref name="pmid31950474"/> and their hybrid forms.<ref name="pmid32163628"/> However, these tumors, particularly in cases that left tumor tissue behind, have had recurrence rates as high as 50% of all cases.<ref name="pmid31950474"/><ref name="pmid17349565"/> The mean time of recurrence after resection was 6.8 years in one large study.<ref name="pmid17349565"/> Recurrent tumors have been treated by a second surgical excision making sure that all tumor tissue is removed.<ref name="pmid12502925"/>

[[Tyrosine kinase inhibitor]] drugs such as [[imatinib]], [[sunitinib]], and [[sorafenib]] have had modest success it treating DFSP tumors located in sites where these tumors are surgical inoperable primary tumors or locally inoperable recurrent tumors or where surgical removal would be disfiguring.<ref name="pmid32516921"/><ref name="pmid27806849">{{cite journal | vauthors = Thway K, Noujaim J, Jones RL, Fisher C | title = Dermatofibrosarcoma protuberans: pathology, genetics, and potential therapeutic strategies | journal = Annals of Diagnostic Pathology | volume = 25 | issue = | pages = 64–71 | date = December 2016 | pmid = 27806849 | doi = 10.1016/j.anndiagpath.2016.09.013 | url = }}</ref><ref name="pmid26189684">{{cite journal | vauthors = Saiag P, Grob JJ, Lebbe C, Malvehy J, del Marmol V, Pehamberger H, Peris K, Stratigos A, Middelton M, Basholt L, Testori A, Garbe C | title = Diagnosis and treatment of dermatofibrosarcoma protuberans. European consensus-based interdisciplinary guideline | journal = European Journal of Cancer (Oxford, England : 1990) | volume = 51 | issue = 17 | pages = 2604–8 | date = November 2015 | pmid = 26189684 | doi = 10.1016/j.ejca.2015.06.108 | url = }}</ref> Some studies have suggested that these inhibitors might be useful for treating similarly inoperable or disfiguring GCF tumors<ref name="pmid31950474"/><ref name="pmid17349565"/> but no formal studies on the use of tyrosine kinase inhibitors in GCF have been as yet reported.


==References==
==References==

Revision as of 16:45, 14 November 2021

Giant cell fibroblastoma
SpecialtyPediatrics, Dermatology, Pathology
SymptomsPainless mass in the dermis
Usual onsetPediatric population
CausesThought to be the formation of a COL1A1-PDGFB fusion gene
TreatmentSurgical excision
PrognosisGood
FrequencyRare

Giant cell fibroblastoma (GCF) is a rare type of soft-tissue tumor marked by painless nodules in the dermis (the inner layer of the two main layers of tissue that make up the skin) and subcutaneous (beneath the skin) tissue. These tumors may come back after surgery, but they do not spread to other parts of the body. They occur mostly in boys.[1] GCF tumor tissues consist of bland spindle-shaped or stellate-shaped cells interspersed among multinucleated giant cells.[2]

GCF tumors are closely related to dermatofibrosarcoma protuberans (DFSP) and dermatofibrosarcoma protuberans, fibrosarcomatous (DFSP-FS) (also termed fibrosarcomatous dermatofibrosarcoma protuberans) tumors.[3] The World Health Organization (2020) classified these three tumors as different tumors in the category of fibroblastic and myofibroblastic tumors with GCF and DFSP sub-classified as benign but aggressive tumors and DFSP-FS subclassified as a rarely metastasizing tumor.[4] However, The three tumor types may contain areas that have a microscopic histopathological appearance similar to one of the other types.[5] Furthermore, following their surgical resection GCF tumors may recur as DFSP tumors and vice versa and DFSP tumors may recur as DFSP-FS tumors. CGF, DFSP, and DFSP-FS have been regarded as an increasingly aggressive spectrum of related tumors.[6]

Giant cell fibroblastoma tumors are typically treated by surgical resection but have a very high rate of recurrence at the sites of their resection, particularly in cases where all of the tumor has not been removed. Accordingly, wide, complete tumor resections are the recommended treatment for them.[6]

Presentation

As found in one study of 86 individuals, GCF commonly present as single tumors in children less than 10 years old (62% of cases), 10-40 year old individuals (26% of cases), and adults greater that 40 years (12% of cases) (overall median age: 6 years).[6] There is a strong predominance of males in the reported cases of GCF.[3][7] The tumors are slow-growing, painless, often protuberant, multinodular or polyp-like dermal and subcutaneous tumors masses or plaques (i.e. a lesion that is greater in its diameter than in its depth) that commonly occur on the trunk, proximal extremities, or rarely the head and neck areas.[3]

Pathology

As defined by microscopic histopathology analyses, GCF tumors consist of a few spindle- and/or stellate-shaped cells in a sclerotic (i.e. collagen fiber-rich) background[8] with distinctive dilated blood vessel-like spaces lined by floret-shaped (i.e. small flower-shaped) multinuclear giant cells.[3] The giant cells vary in size and shape with their nuclei often lined-up in wreath-like or lobular formations.[2] The tumors may infiltrate into and through nearby subcutaneous fat tissue,[2] commonly have intralesional hemorrhages and distinctive perivascular onionskin-like lymphocytes,[6] and occasionally contain nodules of smooth muscle-like cells. Some GCF tumors have hybrid characteristics with areas resembling DFSP (e.g. immature-appearing[7] spindle- and/or stellate-shaped cells with abnormally dark nuclei arranged in a monotonous cartwheel or whorled pattern[6]). These hybrid lesions typical have pure GCF-like areas, pure DFSP-like areas, and mixed areas with a gradual or abrupt transition from one to the other.[7] Surgically removed GCF may recur as a DFSP (and vice versa).[2][6] (DFSP-FS tumors consist of rapidly growing bundles of spindle- and/or stellate-shaped cells with vesicle-containing, abnormally shaped nuclei.[2])

Immunohistochemistry analyses indicate that the tumor cells in GCF express CD34 and vimentin proteins but not epithelial membrane antigen (also termed MUC1),[7] SMA, desmin, HMB-45, keratin, S100,[6] or MLANA (also termed Melan-A) proteins.[5]

Chromosome and gene abnormalities

Cases of GCF consistently contain tumor cells that express a COL1A1-PDGFB fusion gene, i.e. a hybrid gene formed by a chromosomal translocation which mergers two previously independent genes. The COL1A1 gene, which directs production of collagen, type I, alpha 1 protein, is normally located in band 21.33 on the long (or "q") arm of chromosome 17.[9] The PDGFB gene, which directs production of platelet-derived growth factor subunit B (PDGFβ), is normally located in band 13.1 on the q arm of chromosome 22. This translocation is typically balanced, i.e. involving an even exchange of material with no genetic information gained or lost and, ideally, resulting in the formation of a fusion gene which directs production of a fully functional protein. DFSP tumors cells also express a COL1A1-PDGFB fusion gene, but this fusion gene typically results from the formation of small supernumerary ring chromosome, i.e. an extra ring-shaped chromosome that contains a merger between the COL1A1 and PDGFB genes. Hybrid GCF-DFSP tumors typically have more copies of the COL1A1-PDGFB fusion gene in DFSP areas compared to GCF areas and GCF tumors progressing to hybrid GCF-DFSP, GCF progressing to DFSP, and DFSP progressing to DFSP-FS tumors tend to show step-wise increases in the total numbers of these fusion genes that they express.[3]

Either form of the COL1A1-PDGFB fusion gene leads to the overexpression of fully active PDGFβ proteins and thereby the continuous activation of the their target, the PDGF receptor β, along with this receptor β protein-tyrosine kinase activity. The continuously active protein-tyrosine kinase stimulates mitogen-activated protein kinase, PI3K/AKT/mTOR, and other cell signaling pathways which promote the growth, proliferation, and abnormally prolonged survival of their parent cells. It is suggested that these events underlie the development and progression of GCF, GCF-DFSP, DFSP, and DFSP-FS tumors.[8]

Diagnosis

The diagnosis of GCF depends on its presentation as a dermal tumor that has a characteristic histology consisting of spindle- and/or stellate-shaped CD34 protein-expressing cells, distinctive dilated blood vessel-like spaces lined by floret-shaped multinuclear giant cells, and/or distinctive perivascular onionskin-like lymphocytes and/or intralesional hemorrhages[6] in a collagen fiber-rich background.[6][7] Presence of tumor cells containing a COL1A1-PDGFB fusion gene, particularly if it is due to a chromosomal translocation rather than an extra supernumerary chromosome, strongly supports the diagnosis of GCF.[3][7] GSF may have areas with the pathologic and chromosomal findings of DFSP. GCF and these "hybrid" tumors, when surgically resected, often recur and may recur as DFSP tumors.[5]

Treatment and prognosis

Surgical excision with wide surgical margins to ensure the removal of all tumor tissue is the treatment of choice for GCF tumors[3] and their hybrid forms.[5] However, these tumors, particularly in cases that left tumor tissue behind, have had recurrence rates as high as 50% of all cases.[3][6] The mean time of recurrence after resection was 6.8 years in one large study.[6] Recurrent tumors have been treated by a second surgical excision making sure that all tumor tissue is removed.[7]

Tyrosine kinase inhibitor drugs such as imatinib, sunitinib, and sorafenib have had modest success it treating DFSP tumors located in sites where these tumors are surgical inoperable primary tumors or locally inoperable recurrent tumors or where surgical removal would be disfiguring.[8][10][11] Some studies have suggested that these inhibitors might be useful for treating similarly inoperable or disfiguring GCF tumors[3][6] but no formal studies on the use of tyrosine kinase inhibitors in GCF have been as yet reported.

References

  1. ^ Cerio, R. (2012). Dermatopathology. Springer Science & Business Media. ISBN 9783642595523. Retrieved 13 November 2017.
  2. ^ a b c d e Dong SS, Wang N, Yang CP, Zhang GC, Liang WH, Zhao J, Qi Y (2020). "Giant Cell-Rich Solitary Fibrous Tumor in the Nasopharynx: Case Report and Literature Review". OncoTargets and Therapy. 13: 6819–6826. doi:10.2147/OTT.S252696. PMC 7367732. PMID 32764969.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  3. ^ a b c d e f g h i Baranov E, Hornick JL (March 2020). "Soft Tissue Special Issue: Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck". Head and Neck Pathology. 14 (1): 43–58. doi:10.1007/s12105-019-01104-3. PMC 7021862. PMID 31950474.
  4. ^ Sbaraglia M, Bellan E, Dei Tos AP (April 2021). "The 2020 WHO Classification of Soft Tissue Tumours: news and perspectives". Pathologica. 113 (2): 70–84. doi:10.32074/1591-951X-213. PMC 8167394. PMID 33179614.
  5. ^ a b c d Braswell DS, Ayoubi N, Motaparthi K, Walker A (April 2020). "Dermatofibrosarcoma protuberans with features of giant cell fibroblastoma in an adult". Journal of Cutaneous Pathology. 47 (4): 317–320. doi:10.1111/cup.13601. PMID 32163628.
  6. ^ a b c d e f g h i j k l Jha P, Moosavi C, Fanburg-Smith JC (April 2007). "Giant cell fibroblastoma: an update and addition of 86 new cases from the Armed Forces Institute of Pathology, in honor of Dr. Franz M. Enzinger". Annals of Diagnostic Pathology. 11 (2): 81–8. doi:10.1016/j.anndiagpath.2006.12.010. PMID 17349565.
  7. ^ a b c d e f g Terrier-Lacombe MJ, Guillou L, Maire G, Terrier P, Vince DR, de Saint Aubain Somerhausen N, Collin F, Pedeutour F, Coindre JM (January 2003). "Dermatofibrosarcoma protuberans, giant cell fibroblastoma, and hybrid lesions in children: clinicopathologic comparative analysis of 28 cases with molecular data--a study from the French Federation of Cancer Centers Sarcoma Group". The American Journal of Surgical Pathology. 27 (1): 27–39. doi:10.1097/00000478-200301000-00004. PMID 12502925.
  8. ^ a b c Hao X, Billings SD, Wu F, Stultz TW, Procop GW, Mirkin G, Vidimos AT (June 2020). "Dermatofibrosarcoma Protuberans: Update on the Diagnosis and Treatment". Journal of Clinical Medicine. 9 (6). doi:10.3390/jcm9061752. PMC 7355835. PMID 32516921.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  9. ^ https://www.ncbi.nlm.nih.gov/gene/1277
  10. ^ Thway K, Noujaim J, Jones RL, Fisher C (December 2016). "Dermatofibrosarcoma protuberans: pathology, genetics, and potential therapeutic strategies". Annals of Diagnostic Pathology. 25: 64–71. doi:10.1016/j.anndiagpath.2016.09.013. PMID 27806849.
  11. ^ Saiag P, Grob JJ, Lebbe C, Malvehy J, del Marmol V, Pehamberger H, Peris K, Stratigos A, Middelton M, Basholt L, Testori A, Garbe C (November 2015). "Diagnosis and treatment of dermatofibrosarcoma protuberans. European consensus-based interdisciplinary guideline". European Journal of Cancer (Oxford, England : 1990). 51 (17): 2604–8. doi:10.1016/j.ejca.2015.06.108. PMID 26189684.

External links

Public Domain This article incorporates public domain material from Dictionary of Cancer Terms. U.S. National Cancer Institute.


Stub icon

This oncology article is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Giant-cell_fibroblastoma&oldid=1055223398"