Guanylate cyclase activator: Difference between revisions
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rephrased for clarity/fixed typos + added a section describing examples of therapeutic drugs that are GUCAs |
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{{For|the drugs|cinaciguat|riociguat}} |
{{For|the drugs|cinaciguat|riociguat}} |
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A '''guanylate cyclase activator''' (or "'''GUCA'''") is |
A '''guanylate cyclase activator''' (or "'''GUCA'''") is a member of a group of [[Protein|proteins]] that upregulate [[guanylate cyclase]]. '''GUCA''' is also known as '''guanylate cyclase-activating protein''' (or "'''GCAP'''"). Its [[mutations]] can be associated with vision defects.<ref name="pmid94252343">{{cite journal |vauthors=Payne AM, Downes SM, Bessant DA, etal |year=1998 |title=A mutation in guanylate cyclase activator 1A (GUCA1A) in an autosomal dominant cone dystrophy pedigree mapping to a new locus on chromosome 6p21.1 |journal=Hum. Mol. Genet. |volume=7 |issue=2 |pages=273–7 |doi=10.1093/hmg/7.2.273 |pmid=9425234 |doi-access=free}}</ref> |
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There are five genes involved: |
There are five genes involved: |
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* {{Gene|GUCA1A}}, {{Gene|GUCA1B}}, {{Gene|GUCA1C}} |
* {{Gene|GUCA1A}}, {{Gene|GUCA1B}}, {{Gene|GUCA1C}} |
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* {{Gene|GUCA2A}}, {{Gene|GUCA2B}} |
* {{Gene|GUCA2A}}, {{Gene|GUCA2B}} |
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There are several [[Pharmacology|therapeutic drugs]] that act as '''GUCA'''s, including [[linaclotide]] and [[plecanatide]], which are guanylate cyclase-C receptor [[Agonist|agonists]]. These drugs increase the [[secretion]] of [[bicarbonate]] and [[chloride]] in the [[Colon (organ)|colon]] and potentially relieve [[Visceral pain|visceral hypersensitivity]] in [[IBS-C]] patients.<ref>{{Citation |last=Saps |first=Miguel |title=Gastrointestinal Pharmacology |date=2017 |work=Gastrointestinal Pharmacology |volume=239 |pages=147–176 |editor-last=Greenwood-Van Meerveld |editor-first=Beverley |url=http://link.springer.com/10.1007/164_2016_119 |access-date=2024-04-27 |place=Cham |publisher=Springer International Publishing |language=en |doi=10.1007/164_2016_119 |isbn=978-3-319-56359-6 |last2=Miranda |first2=Adrian}}</ref> |
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==References== |
==References== |
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Latest revision as of 18:55, 27 April 2024
A guanylate cyclase activator (or "GUCA") is a member of a group of proteins that upregulate guanylate cyclase. GUCA is also known as guanylate cyclase-activating protein (or "GCAP"). Its mutations can be associated with vision defects.[1]
There are five genes involved:
There are several therapeutic drugs that act as GUCAs, including linaclotide and plecanatide, which are guanylate cyclase-C receptor agonists. These drugs increase the secretion of bicarbonate and chloride in the colon and potentially relieve visceral hypersensitivity in IBS-C patients.[2]
References[edit]
- ^ Payne AM, Downes SM, Bessant DA, et al. (1998). "A mutation in guanylate cyclase activator 1A (GUCA1A) in an autosomal dominant cone dystrophy pedigree mapping to a new locus on chromosome 6p21.1". Hum. Mol. Genet. 7 (2): 273–7. doi:10.1093/hmg/7.2.273. PMID 9425234.
- ^ Saps, Miguel; Miranda, Adrian (2017), Greenwood-Van Meerveld, Beverley (ed.), "Gastrointestinal Pharmacology", Gastrointestinal Pharmacology, vol. 239, Cham: Springer International Publishing, pp. 147–176, doi:10.1007/164_2016_119, ISBN 978-3-319-56359-6, retrieved 2024-04-27
External links[edit]
- Guanylate+Cyclase-Activating+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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