Climbing fiber: Difference between revisions
m Bot: Migrating 2 interwiki links, now provided by Wikidata on d:q4736445 |
No edit summary |
||
| Line 98: | Line 98: | ||
<ref>Wu X, Ashe J, Bushara KO. Role of olivocerebellar system in timing without awareness. Proc Natl Acad Sci U S A 2011.</ref> |
<ref>Wu X, Ashe J, Bushara KO. Role of olivocerebellar system in timing without awareness. Proc Natl Acad Sci U S A 2011.</ref> |
||
Although in the central nervous system, these fibers are able to undergo to remarkable regenerative modifications in response to injuries, being able to generate new branches by sprouting to innervate surrounding Purkinje cells if these lose their CF innervation.<ref name="pmid15177783">{{cite journal | author = Carulli D, Buffo A, Strata P | title = Reparative mechanisms in the cerebellar cortex | journal = Prog Neurobiol | volume = 72 | issue = 6 | pages = 373–98 | year = 2004 | month = April | pmid = 15177783 | doi = 10.1016/j.pneurobio.2004.03.007 | url = http://www.sciencedirect.com/science/article/pii/S0301008204000413 }}</ref> This kind of injury-induced sprouting has been shown to need the growth associated protein [[GAP-43]].<ref name="">{{cite journal | author = Grasselli G, Mandolesi G, Strata P, Cesare P | title = Impaired Sprouting and Axonal Atrophy in Cerebellar Climbing Fibres following In Vivo Silencing of the Growth-Associated Protein GAP-43 | journal = PLoS ONE | volume = 6 | issue = 6 | pages = e20791 | year = 2011| month = June | pmid = | doi = 10.1371/journal.pone.0020791| url = http://www.plosone.org/article/info:doi/10.1371/journal.pone.0020791| issn = }}</ref> |
Although in the central nervous system, these fibers are able to undergo to remarkable regenerative modifications in response to injuries, being able to generate new branches by sprouting to innervate surrounding Purkinje cells if these lose their CF innervation.<ref name="pmid15177783">{{cite journal | author = Carulli D, Buffo A, Strata P | title = Reparative mechanisms in the cerebellar cortex | journal = Prog Neurobiol | volume = 72 | issue = 6 | pages = 373–98 | year = 2004 | month = April | pmid = 15177783 | doi = 10.1016/j.pneurobio.2004.03.007 | url = http://www.sciencedirect.com/science/article/pii/S0301008204000413 }}</ref> This kind of injury-induced sprouting has been shown to need the growth associated protein [[GAP-43]].<ref name="Grasselli et al., 2011">{{cite journal | author = Grasselli G, Mandolesi G, Strata P, Cesare P | title = Impaired Sprouting and Axonal Atrophy in Cerebellar Climbing Fibres following In Vivo Silencing of the Growth-Associated Protein GAP-43 | journal = PLoS ONE | volume = 6 | issue = 6 | pages = e20791 | year = 2011| month = June | pmid = 21695168 | doi = 10.1371/journal.pone.0020791| url = http://www.plosone.org/article/info:doi/10.1371/journal.pone.0020791| issn = }}</ref> <ref name="Grasselli & Strata, 2013">{{cite journal | author = Grasselli G, Strata P | title = Structural plasticity of climbing fibers and the growth-associated protein GAP-43 | journal = Front. Neural Circuits | volume = 7 | issue = 25 | year = 2013 | month = February | pmid = 23441024 | doi = 10.3389/fncir.2013.00025| url = http://www.frontiersin.org/neural_circuits/10.3389/fncir.2013.00025/abstract| issn = }}</ref> |
||
==See also== |
==See also== |
||
Revision as of 16:07, 19 March 2013
| Climbing fiber | |
|---|---|
| Details | |
| Location | Inferior Olive and Cerebellum |
| Shape | Unique projection neuron (see text) |
| Function | Unique excitatory function (see text) |
| Presynaptic connections | Inferior olive |
| Postsynaptic connections | Purkinje cells |
| Anatomical terms of neuroanatomy | |
Climbing fibers are the name given to a series of neuronal projections from the inferior olivary nucleus located in the medulla oblongata.[1][2]
These axons pass through the pons and enter the cerebellum via the inferior cerebellar peduncle where they form synapses with the deep cerebellar nuclei and Purkinje cells. Each climbing fiber will form synapses with 1-10 Purkinje cells.
Early in development, Purkinje cells are innervated by multiple climbing fibers, but as the cerebellum matures, these inputs gradually become eliminated resulting in a single climbing fiber input per Purkinje cell.
These fibers provide very powerful, excitatory input to the cerebellum which results in the generation of complex spike excitatory postsynaptic potential (EPSP) in Purkinje cells.[1] In this way climbing fibers (CFs) perform a central role in motor behaviors.[3]
The climbing fibers carry information from various sources such as the spinal cord, vestibular system, red nucleus, superior colliculus, reticular formation and sensory and motor cortices. Climbing fiber activation is thought to serve as a motor error signal sent to the cerebellum, and is an important signal for motor timing. In addition to the control and coordination of movements,[4] the climbing fiber afferent system contributes to sensory processing and cognitive tasks likely by encoding the timing of sensory input independently of attention or awareness .[5][6] [7]
Although in the central nervous system, these fibers are able to undergo to remarkable regenerative modifications in response to injuries, being able to generate new branches by sprouting to innervate surrounding Purkinje cells if these lose their CF innervation.[8] This kind of injury-induced sprouting has been shown to need the growth associated protein GAP-43.[9] [10]
See also
References
- ^ a b
Harting, John K. (1996,1997). "Cerebellum - Circuitry - Climbing Fibers". Retrieved 2008-12-25.
{{cite web}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^
Bear, Mark F. (2006). Neuroscience: Exploring the Brain (Digitised online by Google Books). Lippincott Williams & Wilkins. p. 773. ISBN 0-7817-6003-8, 9780781760034. Retrieved 2008-12-25.
{{cite book}}: Check|isbn=value: invalid character (help); Cite has empty unknown parameter:|month=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) Image of Parallel fiber - ^
McKay, Bruce E.; Engbers, Jordan D. T., W. Hamish Mehaffey, Grant R. J. Gordon, Michael L. Molineux,
Jaideep S. Bains, and Ray W. Turner; Mehaffey, WH; Gordon, GR; Molineux, ML; Bains, JS; Turner, RW (January 31, 2007). "Climbing Fiber Discharge Regulates Cerebellar Functions by Controlling the Intrinsic Characteristics of Purkinje Cell Output" (PDF). Journal of neurophysiology. 97 (4). J Neurophysiol: 2590–604. doi:10.1152/jn.00627.2006. PMID 17267759. Retrieved 2008-12-25.
{{cite journal}}: line feed character in|first2=at position 76 (help)CS1 maint: multiple names: authors list (link) - ^ "Medical Neurosciences".
- ^ Xu D, Liu T, Ashe J, Bushara KO. Role of the olivo-cerebellar system in timing. J Neurosci 2006; 26: 5990-5.
- ^ Liu T, Xu D, Ashe J, Bushara K. Specificity of inferior olive response to stimulus timing. J Neurophysiol 2008; 100: 1557-61.
- ^ Wu X, Ashe J, Bushara KO. Role of olivocerebellar system in timing without awareness. Proc Natl Acad Sci U S A 2011.
- ^ Carulli D, Buffo A, Strata P (2004). "Reparative mechanisms in the cerebellar cortex". Prog Neurobiol. 72 (6): 373–98. doi:10.1016/j.pneurobio.2004.03.007. PMID 15177783.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Grasselli G, Mandolesi G, Strata P, Cesare P (2011). "Impaired Sprouting and Axonal Atrophy in Cerebellar Climbing Fibres following In Vivo Silencing of the Growth-Associated Protein GAP-43". PLoS ONE. 6 (6): e20791. doi:10.1371/journal.pone.0020791. PMID 21695168.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ Grasselli G, Strata P (2013). "Structural plasticity of climbing fibers and the growth-associated protein GAP-43". Front. Neural Circuits. 7 (25). doi:10.3389/fncir.2013.00025. PMID 23441024.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: unflagged free DOI (link)