|NeuroLex ID||Fastigial nucleus|
|Anatomical terms of neuroanatomy|
The fastigial nucleus or nucleus fastigii is located in the cerebellum. It is one of the deep cerebellar nuclei (the others being the nucleus dentatus, nucleus emboliformis and nucleus globosus), and is grey matter embedded in the white matter of the cerebellum.
It refers specifically to the concentration of gray matter nearest to the middle line at the anterior end of the superior vermis, and immediately over the roof of the fourth ventricle, from which it is separated by a thin layer of white matter. It is smaller than the nucleus dentatus, but somewhat larger than the nucleus emboliformis and nucleus globosus. The fastigial nucleus is the smallest in size, with the dentate being the largest and the interposed being intermediate in size.
Although it is one dense mass, it is made up of two sections: the rostral fastigial nucleus and the caudal fastigial nucleus.
The Purkinje cells of the cerebellar cortex project into the deep cerebellar nuclei and inhibit the excitatory output system via GABAergic synapses. The fastigial nucleus receives its afferent input from Purkinje cells in the vermis. Most of its efferent connections travel via the inferior cerebellar peduncle to the vestibular nuclei, which are located at the junction of the pons and the medulla oblongata.
Rostral Fastigial Nucleus
The rostral fastigial nucleus (rFN) is related to vestibular system. It receives input from the vestibular nuclei and contributes to vestibular neuronal activity. The rFN interprets body motion and places it on spatial planes to estimate the movement of the body through space. It deals with antigravity muscle groups and other synergies involved with standing and walking.
Caudal Fastigial Nucleus
The caudal fastigial nucleus (cFN) is related to saccadic eye movements. The Purkinje cell output from the oculomotor vermis relays through the cFN, where neurons directly related to saccadic eye movements are located.
- John K. Harting, Ph.D. (1997). "The Global Cerebellum '97". University of Wisconsin Medical School. Retrieved 2007-06-28.
- Brooks & Cullen, <http://www.jneurosci.org/content/29/34/10499.full.pdf> [Multimodal integration in rostral fastigial nucleus provides an estimate of body movement], 2009
- James D. Geyer, Janice M. Keating, Daniel C. Potts (1998). Neurology for the Boards. Philadelphia: Lippincott-Raven. p. 9.
- Kleine, Guan, & Buttner, <http://jn.physiology.org/content/90/5/3137.full.pdf+html> [Saccade-related neurons in the primate fastigial nucleus: what do they encode?], 2003
- Illustration and text: cere/text/P5/fastig.htm at the University of Wisconsin-Madison Medical school
- NIF Search - Fastigial Nucleus via the Neuroscience Information Framework