Basket cell

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Neuron: Basket cell
Basket cell - Transverse section of a cerebellar folium (Basket cell labeled at bottom left)
Transverse section of a cerebellar folium (Basket cell labeled at bottom left)
Location Cerebellum
Function Inhibitory interneuron
Morphology multipolar
Presynaptic connections Parallel fibers
Postsynaptic connections Purkinje cells
NeuroLex ID nifext_160

Basket cells are inhibitory GABAergic interneurons found in several brain regions: the molecular layer of the cerebellum, the hippocampus, and the cortex.[1]

Contents

Cerebellum [edit]

Micrograph of cerebellar cortex showing Purkinje cells within the baskets formed by the processes of basket cells. Bielschowsky stain.

In the cerebellum, they synapse on the cell bodies of Purkinje cells, and are multipolar and stellate, with freely branching dendrites, which are dilated and knotty.

Hippocampus [edit]

Hippocampal basket cells target somata and proximal dendrites of pyramidal neurons. Cortical[2] and hippocampal basket cells are parvalbumin-expressing and fast-spiking.

Cortex [edit]

In the cortex, basket cells have sparsely branched axons giving off small pericellular, basket-shaped elaborations at several intervals along their length. There are three types of basket cells in the cortex, the small, large and nest type:[3] The axon of a small basket cell arborizes in the vicinity of that same cell's dendritic range. In contrast, large basket cells innervate somata in different cortical columns. The nest basket cells are an intermediate form of the small and large cells, their axons are confined mainly to the same cortical layer as their somata.

Additional images [edit]

External links [edit]

References [edit]

  1. ^ Jones, Edward (1984). Cerebral Cortex: Volume 1: Cellular Components of the Cerebral Cortex. Springer. ISBN 9780306415449. 
  2. ^ Contreras, D. (2004). "Electrophysiological classes of neocortical neurons". Neural Networks 17 (5–6): 633–646. doi:10.1016/j.neunet.2004.04.003. PMID 15288889.  edit
  3. ^ Fox, K. "Barrel Cortex", Cambridge University Press, pp. 55-56