APLP2

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Amyloid precursor-like protein 2, also known as APLP2, is a protein that in humans is encoded by the APLP2 gene.[1][2] APLP2 along with APLP1 are important modulators of glucose and insulin homeostasis.[3]

Function[edit]

APLP2 associates with antigen presentation molecules like MHC class I molecules and regulates their surface expression by enhancing endocytosis.[4][5]

APLP1 and APLP2 double knockout mice display hypoglycemia and hyperinsulinemia indicating that these two proteins are important modulators of glucose and insulin homeostasis.[3] APLP2 has also been shown to regulate development of the brain by regulating migration and differentiation of neural stem cells.[6]

Interactions[edit]

APLP2 has been shown to interact with APBB1 and Netrin-1 .[7][8]

References[edit]

  1. ^ "Entrez Gene: APLP2 Amyloid beta (A4) precursor-like protein 2". 
  2. ^ Leach R, Ko M, Krawetz SA (1999). "Assignment of amyloid-precursor-like protein 2 gene (APLP2) to 11q24 by fluorescent in situ hybridization". Cytogenet. Cell Genet. 87 (3–4): 215–6. doi:10.1159/000015472. PMID 10702673. 
  3. ^ a b Needham BE, Wlodek ME, Ciccotosto GD, Fam BC, Masters CL, Proietto J, Andrikopoulos S, Cappai R (June 2008). "Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth". J. Pathol. 215 (2): 155–63. doi:10.1002/path.2343. PMID 18393365. 
  4. ^ Tuli A, Sharma M, Naslavsky N, Caplan S, Solheim JC (June 2008). "Specificity of amyloid precursor-like protein 2 interactions with MHC class I molecules". Immunogenetics 60 (6): 303–13. doi:10.1007/s00251-008-0296-0. PMC 2683759. PMID 18452037. 
  5. ^ Tuli A, Sharma M, McIlhaney MM, Talmadge JE, Naslavsky N, Caplan S, Solheim JC (August 2008). "Amyloid precursor-like protein 2 increases the endocytosis, instability, and turnover of the H2-K(d) MHC class I molecule". J. Immunol. 181 (3): 1978–87. doi:10.4049/jimmunol.181.3.1978. PMC 2607064. PMID 18641335. 
  6. ^ Shariati Sa, APLP2 regulates neuronal stem cell differentiation during cortical development, 2013, Journal of Cell Science.
  7. ^ Guénette SY, Chen J, Jondro PD, Tanzi RE (October 1996). "Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein". Proc. Natl. Acad. Sci. U.S.A. 93 (20): 10832–7. doi:10.1073/pnas.93.20.10832. PMC 38241. PMID 8855266. 
  8. ^ Tanahashi H, Tabira T (February 1999). "Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein". Neurosci. Lett. 261 (3): 143–6. doi:10.1016/S0304-3940(98)00995-1. PMID 10081969. 

Further reading[edit]

  • Blangy A, Vidal F, Cuzin F, et al. (1995). "CDEBP, a site-specific DNA-binding protein of the 'APP-like' family, is required during the early development of the mouse". J. Cell. Sci. 108 (2): 675–83. PMID 7539437. 
  • von der Kammer H, Hanes J, Klaudiny J, Scheit KH (1995). "A human amyloid precursor-like protein is highly homologous to a mouse sequence-specific DNA-binding protein". DNA Cell Biol. 13 (11): 1137–43. doi:10.1089/dna.1994.13.1137. PMID 7702756. 
  • Bush AI, Pettingell WH, de Paradis M, et al. (1994). "The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily". J. Biol. Chem. 269 (43): 26618–21. PMID 7929392. 
  • von der Kammer H, Löffler C, Hanes J, et al. (1994). "The gene for the amyloid precursor-like protein APLP2 is assigned to human chromosome 11q23-q25". Genomics 20 (2): 308–11. doi:10.1006/geno.1994.1174. PMID 8020984. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Wasco W, Gurubhagavatula S, Paradis MD, et al. (1993). "Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor". Nat. Genet. 5 (1): 95–100. doi:10.1038/ng0993-95. PMID 8220435. 
  • Sprecher CA, Grant FJ, Grimm G, et al. (1993). "Molecular cloning of the cDNA for a human amyloid precursor protein homolog: evidence for a multigene family". Biochemistry 32 (17): 4481–6. doi:10.1021/bi00068a002. PMID 8485127. 
  • Guénette SY, Chen J, Jondro PD, Tanzi RE (1996). "Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein". Proc. Natl. Acad. Sci. U.S.A. 93 (20): 10832–7. doi:10.1073/pnas.93.20.10832. PMC 38241. PMID 8855266. 
  • Bressler SL, Gray MD, Sopher BL, et al. (1997). "cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein". Hum. Mol. Genet. 5 (10): 1589–98. doi:10.1093/hmg/5.10.1589. PMID 8894693. 
  • Suzuki T, Ando K, Isohara T, et al. (1997). "Phosphorylation of Alzheimer beta-amyloid precursor-like proteins". Biochemistry 36 (15): 4643–9. doi:10.1021/bi962618k. PMID 9109675. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Duilio A, Faraonio R, Minopoli G, et al. (1998). "Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein". Biochem. J. 330 (1): 513–9. PMC 1219167. PMID 9461550. 
  • Lyckman AW, Confaloni AM, Thinakaran G, et al. (1998). "Post-translational processing and turnover kinetics of presynaptically targeted amyloid precursor superfamily proteins in the central nervous system". J. Biol. Chem. 273 (18): 11100–6. doi:10.1074/jbc.273.18.11100. PMID 9556595. 
  • Tanahashi H, Tabira T (1999). "Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein". Neurosci. Lett. 261 (3): 143–6. doi:10.1016/S0304-3940(98)00995-1. PMID 10081969. 
  • Homayouni R, Rice DS, Sheldon M, Curran T (1999). "Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1". J. Neurosci. 19 (17): 7507–15. PMID 10460257. 
  • Mitsuuchi Y, Johnson SW, Sonoda G, et al. (1999). "Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2". Oncogene 18 (35): 4891–8. doi:10.1038/sj.onc.1203080. PMID 10490823. 
  • Leach R, Ko M, Krawetz SA (2000). "Assignment of amyloid-precursor-like protein 2 gene (APLP2) to 11q24 by fluorescent in situ hybridization". Cytogenet. Cell Genet. 87 (3–4): 215–6. doi:10.1159/000015472. PMID 10702673. 
  • Xu KP, Zoukhri D, Zieske JD, et al. (2001). "A role for MAP kinase in regulating ectodomain shedding of APLP2 in corneal epithelial cells". Am. J. Physiol., Cell Physiol. 281 (2): C603–14. PMID 11443060. 
  • Yarden RI, Brody LC (2002). "Identification of proteins that interact with BRCA1 by Far-Western library screening". J. Cell. Biochem. 83 (4): 521–31. doi:10.1002/jcb.1257. PMID 11746496. 
  • Scheinfeld MH, Ghersi E, Laky K, et al. (2003). "Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription". J. Biol. Chem. 277 (46): 44195–201. doi:10.1074/jbc.M208110200. PMID 12228233.