Accelerated phase chronic myelogenous leukemia

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Accelerated phase chronic myelogenous leukemia
Classification and external resources
MeSH D015465

Accelerated phase chronic myelogenous leukemia is a phase of chronic myelogenous leukemia in which the disease is progressing.[1] In this phase, 10-19 % of the cells in the blood and bone marrow are blast cells (immature blood cells).In accelerated phase, Leukemia cells grow quickly and common symptoms include fever, bone pain, swollen spleen, etc.[2] Prognosis is very poor once chronic myelogenous leukemia reaches the accelerated phase-it behaves similary to acute myeloid leukemia.Patients treated with imatinib, dasatinib, and nilotinib have shown meaningful rates of hematologic and cytogenetic response.[3]


  1. ^ Moshe Talpaz (2002). "Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study". Blood 99 (6): 1928–1937. doi:10.1182/blood.v99.6.1928. 
  2. ^ "Chronic myelogenous leukemia (CML)". 
  3. ^ Shah, NP (Mar 2008). "Advanced CML: therapeutic options for patients in accelerated and blast phases.". Journal of the National Comprehensive Cancer Network : JNCCN. 6 Suppl 2: S31–S36. PMID 18397679. 

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