Lineage. Captions in Polish, but "GMP" visible near bottom center.
CFU-GM (or "GMP", for "granulocyte-macrophage progenitor") is a colony forming unit. It is derived from CFU-GEMM.
The "GM" stands for "granulocyte, monocyte".
It is the precursor for monoblasts and myeloblasts.
Production is stimulated by granulocyte macrophage colony-stimulating factor (GM-CSF).
There is some controversy over which granulocytes derive from CFU-GM.
- There is little disagreement that neutrophils come from CFU-GM.
- Other sources state that basophils do not derive from CFU-GM, but from a distinct CFU, titled "CFU-Baso".
- ^ "Hem I WBC Morphology and Physiology". Retrieved 2008-12-30.
- ^ Ganong, William F.; McPhee, Stephen J.; Lingappa, Vishwanath R. (2005). Pathophysiology of Disease: An Introduction to Clinical Medicine (Lange). McGraw-Hill Medical. p. 107. ISBN 0-07-144159-X.
- ^ Rudolph, Colin David (2003). Rudolph's pediatrics. New York: McGraw-Hill, Medical Pub. Division. p. 1563. ISBN 0-8385-8285-0.