The anterior chamber (AC) is the fluid-filled space inside the eye between the iris and the cornea's innermost surface, the endothelium.Aqueous humor is the fluid that fills the anterior chamber. Hyphema and glaucoma are two main pathologies in this area. In hyphema, blood fills the anterior chamber. In glaucoma, blockage of the canal of Schlemm prevents the normal outflow of aqueous humor, resulting in accumulation of fluid, increased intraocular pressure, and eventually blindness.The normal depth of anterior chamber of eye 3.5mm to 2.5mm, less than 2.5mm depth can be risk for angle closure glaucoma.
One peculiar feature of the anterior chamber is dampened immune response to allogenic grafts. This is called anterior chamber associated immune deviation (ACAID), a term introduced in 1981 by Streilein et al.