Anterior cingulate cortex
|Brain: Anterior cingulate cortex|
Medial surface of left cerebral hemisphere, with anterior cingulate highlighted.
Medial surface of right hemisphere, with Brodmann's areas numbered.
|Latin||Cortex cingularis anterior|
The anterior cingulate cortex (ACC) is the frontal part of the cingulate cortex that resembles a "collar" surrounding the frontal part of the corpus callosum. It consists of Brodmann areas 24, 32, and 33.
The anterior cingulate cortex can be divided anatomically based on cognitive (dorsal), and emotional (ventral) components. The dorsal part of the ACC is connected with the prefrontal cortex and parietal cortex as well as the motor system and the frontal eye fields making it a central station for processing top-down and bottom-up stimuli and assigning appropriate control to other areas in the brain. By contrast, the ventral part of the ACC is connected with amygdala, nucleus accumbens, hypothalamus, and anterior insula, and is involved in assessing the salience of emotion and motivational information. The ACC seems to be especially involved when effort is needed to carry out a task such as in early learning and problem-solving.
On a cellular level, the ACC is unique in its abundance of specialized neurons called spindle cells. These cells are a relatively recent occurrence in evolutionary terms (found only in humans and other great apes, cetaceans, and elephants) and contribute to this brain region's emphasis on addressing difficult problems, as well as the pathologies related to the ACC.
A typical task that activates the ACC involves eliciting some form of conflict within the participant that can potentially result in an error. One such task is called the Eriksen flanker task and consists of an arrow pointing to the left or right, which is flanked by two distractor arrows creating either compatible (<<<<<) or incompatible (<<<>>) trials. Another very common conflict-inducing stimulus is the Stroop task (Pardo et al., 1990), which involves naming the color ink of words that are either congruent (RED written in red) or incongruent (RED written in blue). Conflict occurs because people’s reading abilities interfere with their attempt to correctly name the word’s ink color. A variation of this task is the Counting-Stroop, during which people count either neutral stimuli (‘dog’ presented four times) or interfering stimuli (‘three’ presented four times) by pressing a button. Another version of the Stroop task named the Emotional Counting Stroop is identical to the Counting Stroop test, except that it also uses segmented or repeated emotional words such as "murder" during the interference part of the task.
Error detection and conflict monitoring
The most basic form of ACC theory states that the ACC is involved with error detection. Evidence has been derived from studies involving a Stroop task. However, ACC is also active during correct response, and this has been shown using a letter task, whereby participants had to respond to the letter X after an A was presented and ignore all other letter combinations with some letters more competitive than others. They found that for more competitive stimuli ACC activation was greater.
A similar theory poses that the ACC’s primary function is the monitoring of conflict. In Eriksen flanker task, incompatible trials produce the most conflict and the most activation by the ACC. Upon detection of a conflict, the ACC then provides cues to other areas in the brain to cope with the conflicting control systems.
- Evidence from electrical studies
Evidence for ACC as having an error detection function comes from observations of error-related negativity (ERN) uniquely generated within the ACC upon error occurrences. A distinction has been made between an ERP following incorrect responses (response ERN) and a signal after subjects receive feedback after erroneous responses (feedback ERN).
Reinforcement learning ERN theory poses that there is a mismatch between actual response execution and appropriate response execution, which results in an ERN discharge. Furthermore, this theory predicts that, when the ACC receives conflicting input from control areas in the brain, it determines and allocates which area should be given control over the motor system. Varying levels of dopamine are believed to influence the optimization of this filter system by providing expectations about the outcomes of an event. The ERN, then, serves as a beacon to highlight the violation of an expectation. Research on the occurrence of the feedback ERN shows evidence that this potential has larger amplitudes when violations of expectancy are large. In other words, if an event is not likely to happen, the feedback ERN will be larger if no error is detected. Other studies have examined whether the ERN is elicited by varying the cost of an error and the evaluation of a response.
In these trials, feedback is given about whether the participant has gained or lost money after a response. Amplitudes of ERN responses with small gains and small losses were similar. No ERN was elicited for any losses as opposed to an ERN for no wins, even though both outcomes are the same. The finding in this paradigm suggests that monitoring for wins and losses is based on the relative expected gains and losses. If you get a different outcome than expected, the ERN will be larger than for expected outcomes. ERN studies have also localized specific functions of the ACC.
The rostral ACC seems to be active after an error commission, indicating an error response function, whereas the dorsal ACC is active after both an error and feedback, suggesting a more evaluative function (for fMRI evidence, see also ). This evaluation is emotional in nature and highlights the amount of distress associated with a certain error. Summarizing the evidence found by ERN studies, it appears to be the case that ACC receives information about a stimulus, selects an appropriate response, monitors the action, and adapts behavior if there is a violation of expectancy.
- Evidence against error detection and conflict monitoring theory
Studies examining task performance related to error and conflict processes in patients with ACC damage cast doubt on the necessity of this region for these functions. The error detection and conflict monitoring theories cannot explain some evidence obtained by electrical studies that demonstrate the effects of giving feedback after responses because the theory describes the ACC as strictly monitoring conflict, not as having evaluative properties.
It has been stated that "The cognitive consequences of anterior cingulate lesions remain rather equivocal, with a number of case reports of intact general neuropsychological and executive function in the presence of large anterior dorsal cingulate lesions. For an alternative view of anterior cingulate, see Rushworth's review (2007).
Reward-based learning theory
A more comprehensive and recent theory describes the ACC as a more active component and poses that it detects and monitors errors, evaluates the degree of the error, and then suggests an appropriate form of action to be implemented by the motor system. Earlier evidence from electrical studies indicate the ACC has an evaluative component, which is indeed confirmed by fMRI studies. The dorsal and rostral areas of the ACC both seem to be affected by rewards and losses associated with errors. During one study, participants received monetary rewards and losses for correct and incorrect responses, respectively.
Largest activation in the dACC was shown during loss trials. This stimulus did not elicit any errors, and, thus, error detection and monitoring theories cannot fully explain why this ACC activation would occur. The dorsal part of the ACC seems to play a key role in reward-based decision-making and learning. The rostral part of the ACC, on the other hand, is believed to be involved more with affective responses to errors. In an interesting expansion of the previously described experiment, the effects of rewards and costs on ACC’s activation during error commission was examined. Participants performed a version of the Eriksen flanker task using a set of letters assigned to each response button instead of arrows.
Targets were flanked by either a congruent or an incongruent set of letters. Using an image of a thumb (up, down, or neutral), participants received feedback on how much money they gained or lost. The researchers found greater rostral ACC activation when participants lost money during the trials. The participants reported being frustrated when making mistakes. Because the ACC is intricately involved with error detection and affective responses, it may very well be that this area forms the bases of self-confidence. Taken together, these findings indicate that both the dorsal and rostral areas are involved in evaluating the extent of the error and optimizing subsequent responses. A study confirming this notion explored the functions of both the dorsal and rostral areas of the ACC involved using a saccade task.
Participants were shown a cue that indicated whether they had to make either a pro-saccade or an anti-saccade. An anti-saccade requires suppression of a distracting cue because the target appears in the opposite location causing the conflict. Results showed differing activation for the rostral and dorsal ACC areas. Early correct anti-saccade performance was associated with rostral activation. The dorsal area, on the other hand, was activated when errors were committed, but also for correct responses.
Whenever the dorsal area was active, fewer errors were committed providing more evidence that the ACC is involved with effortful performance. The second finding showed that, during error trials, the ACC activated later than for correct responses, clearly indicating a kind of evaluative function.
Role in consciousness
The ACC area in the brain is associated with many functions that are correlated with conscious experience. Greater ACC activation levels were present in more emotionally-aware female participants when shown short ‘emotional’ video clips. Better emotional awareness is associated with improved recognition of emotional cues or targets, which is reflected by ACC activation.
The idea of awareness being associated with the ACC has some evidence with it, in that it seems to be the case that, when subjects' responses are not congruent with actual responses, a larger error-related negativity is produced.
One study found an ERN even when subjects were not aware of their error. Awareness may not be necessary to elicit an ERN, but it could influence the effect of the amplitude of the feedback ERN. Relating back to the reward-based learning theory, awareness could modulate expectancy violations. Increased awareness could result in decreased violations of expectancies and decreased awareness could achieve the opposite effect. Further research is needed to completely understand the effects of awareness on ACC activation.
In The Astonishing Hypothesis, Francis Crick identifies the anterior cingulate, to be specific the anterior cingulate sulcus, as a likely candidate for the center of free will in humans. Crick bases this suggestion on scans of patients with specific lesions that seem to interfere with their sense of independent will, such as alien hand syndrome.
Role in registering pain
The ACC registers physical pain as shown in functional MRI studies that showed an increase in signal intensity, typically in the posterior part of area 24 of the ACC, that was correlated with pain intensity. When this pain-related activation was accompanied by attention-demanding cognitive tasks (verbal fluency), the attention-demanding tasks increased signal intensity in a region of the ACC anterior and/or superior to the pain-related activation region. The ACC is the cortical area that has been most frequently linked to the experience of pain. It appears to be involved in the emotional reaction to pain rather than to the perception of pain itself.
Studying the effects of damage to the ACC provides insights into the type of functions it serves in the intact brain. Behavior that is associated with lesions in the ACC includes: inability to detect errors, severe difficulty with resolving stimulus conflict in a Stroop task, emotional instability, inattention, and akinetic mutism. There is evidence that damage to ACC is present in patients with schizophrenia, where studies have shown patients have difficulty in dealing with conflicting spatial locations in a Stroop-like task and having abnormal ERNs. Participants with ADHD were found to have reduced activation in the dorsal area of the ACC when performing the Stroop task. Together, these findings corroborate results from imaging and electrical studies about the variety of functions attributed to the ACC.
There is evidence that this area may have a role in obsessive–compulsive disorder due to the fact that what appears to be an unnaturally low level of glutamate activity in this region has been observed in patients with the disorder, in contrast to many other brain regions that are thought to have excessive glutamate activity in OCD. Recent SDM meta-analyses of voxel-based morphometry studies comparing people with OCD and healthy controls has found people with OCD to have increased grey matter volumes in bilateral lenticular nuclei, extending to the caudate nuclei, while decreased grey matter volumes in bilateral dorsal medial frontal/anterior cingulate cortex. These findings contrast with those in people with other anxiety disorders, who evince decreased (rather than increased) grey matter volumes in bilateral lenticular / caudate nuclei, while also decreased grey matter volumes in bilateral dorsal medial frontal / anterior cingulate gyri.
A study of brain MRIs taken on adults that had previously participated in the Cincinnati Lead Study found that people that had suffered higher levels of lead exposure as children had decreased brain size as adults. This effect was most pronounced in the ACC (Cecil et al., 2008) and is thought to relate to the cognitive and behavioral deficits of affected individuals.
Impairments in the development of the anterior cingulate, together with impairments in the dorsal medial-frontal cortex, may constitute a neural substrate for socio-cognitive deficits in autism, such as social orienting and joint attention.
Anterior Cingulate Cortex of monkey (Macaca mulatta).
|Wikimedia Commons has media related to Anterior cingulate cortex.|
- Hewitt, John (26 March 2013). "Predicting repeat offenders with brain scans: You be the judge". medicalxpress.com. Retrieved 2013-03-26.
- Decety, J.; Jackson, P. L. (2004). "The Functional Architecture of Human Empathy". Behavioral and Cognitive Neuroscience Reviews 3 (2): 71–100. doi:10.1177/1534582304267187. PMID 15537986.
- Jackson P.L., Brunet E., Meltzoff A.N., Decety J. (2006). "Empathy examined through the neural mechanisms involved in imagining how I feel versus how you feel pain: An event-related fMRI study". Neuropsychologia 44: 752–61. doi:10.1016/j.neuropsychologia.2005.07.015.
- Bush G, Luu P, Posner MI (June 2000). "Cognitive and emotional influences in anterior cingulate cortex". Trends Cogn Sci. 4 (6): 215–222. doi:10.1016/S1364-6613(00)01483-2. PMID 10827444.
- Posner MI, DiGirolamo GJ (1998). "Executive attention: Conflict, target detection, and cognitive control". In Parasuraman R. The attentive brain. Cambridge, Mass: MIT Press. ISBN 0-262-16172-9.
- Allman JM, Hakeem A, Erwin JM, Nimchinsky E, Hof P (May 2001). "The anterior cingulate cortex. The evolution of an interface between emotion and cognition". Ann N Y Acad Sci. 935 (1): 107–17. doi:10.1111/j.1749-6632.2001.tb03476.x. PMID 11411161.
- Carter, Rita. The Human Brain Book. p. 124.
- Allman, John; Atiya Hakeem, Esther Nimchinsky, Patrick Hof (2006). "The Anterior Cingulate Cortex". Annals of the New York Academy of Sciences. doi:10.1111/j.1749-6632.2001.tb03476.x. PMID 11411161.
- Botvinick M, Nystrom LE, Fissell K, Carter CS, Cohen JD (November 1999). "Conflict monitoring versus selection-for-action in anterior cingulate cortex". Nature 402 (6758): 179–81. doi:10.1038/46035. PMID 10647008.
- Weissman, D. H.; Gopalakrishnan, A.; Hazlett, C. J.; Woldorff, M. G. (2004). "Dorsal Anterior Cingulate Cortex Resolves Conflict from Distracting Stimuli by Boosting Attention toward Relevant Events". Cerebral Cortex 15 (2): 229–237. doi:10.1093/cercor/bhh125. PMID 15238434.
- Nieuwenhuis S, Ridderinkhof KR, Blom J, Band GP, Kok A (September 2001). "Error-related brain potentials are differentially related to awareness of response errors: evidence from an antisaccade task". Psychophysiology 38 (5): 752–60. doi:10.1111/1469-8986.3850752. PMID 11577898.
- Carter CS, Braver TS, Barch DM, Botvinick MM, Noll D, Cohen JD (May 1998). "Anterior cingulate cortex, error detection, and the online monitoring of performance". Science 280 (5364): 747–9. doi:10.1126/science.280.5364.747. PMID 9563953.
- Gehring WJ, Goss B, Coles MGH, Meyer DE, Donchin E (November 1993). "A neural system for error-detection and compensation". Psychological Science 4 (6): 385–90. doi:10.1111/j.1467-9280.1993.tb00586.x.
- Holroyd CB, Nieuwenhuis S, Mars RB, Coles MGH (2004). "Anterior cingulate cortex, selection for action, and error processing". In Posner MI. Cognitive neuroscience of attention. New York: Guilford Press. pp. 219–31. ISBN 1-59385-048-4.
- Luu P, Pederson SM (2004). "The anterior cingulate cortex: Regulating actions in context". In Posner MI. Cognitive neuroscience of attention. New York: Guilford Press. ISBN 1-59385-048-4.
- Gehring WJ, Knight RT (May 2000). "Prefrontal-cingulate interactions in action monitoring". Nat Neurosci. 3 (5): 516–20. doi:10.1038/74899. PMID 10769394.
- Bush G, Vogt BA, Holmes J, et al. (January 2002). "Dorsal anterior cingulate cortex: a role in reward-based decision making". Proc Natl Acad Sci USA. 99 (1): 523–8. doi:10.1073/pnas.012470999. PMC 117593. PMID 11756669.
- Polli FE, Barton JJ, Cain MS, Thakkar KN, Rauch SL, Manoach DS (October 2005). "Rostral and dorsal anterior cingulate cortex make dissociable contributions during antisaccade error commission". Proc Natl Acad Sci USA. 102 (43): 15700–5. doi:10.1073/pnas.0503657102. PMC 1255733. PMID 16227444.
- Taylor SF, Martis B, Fitzgerald KD, et al. (April 2006). "Medial frontal cortex activity and loss-related responses to errors". J Neurosci. 26 (15): 4063–70. doi:10.1523/JNEUROSCI.4709-05.2006. PMID 16611823.
- Critchley HD (December 2005). "Neural mechanisms of autonomic, affective, and cognitive integration". J Comp Neurol. 493 (1): 154–66. doi:10.1002/cne.20749. PMID 16254997.
See Review by Critchely related to this
- Rushworth MF, Behrens TE, Rudebeck PH, Walton ME (April 2007). "Contrasting roles for cingulate and orbitofrontal cortex in decisions and social behaviour". Trends Cogn Sci. 11 (4): 168–76. doi:10.1016/j.tics.2007.01.004. PMID 17337237.
- Lane RD, Reiman EM, Axelrod B, Yun LS, Holmes A, Schwartz GE (July 1998). "Neural correlates of levels of emotional awareness. Evidence of an interaction between emotion and attention in the anterior cingulate cortex". J Cogn Neurosci 10 (4): 525–35. doi:10.1162/089892998562924. PMID 9712681.
- Davis, Karen D., Stephen J. Taylor, Adrian P. Crawley, Michael L. Wood, and David J. Mikulis. "Functional MRI of pain- and attention-related activations in the human cingulate cortex", J. Neurophysiol. volume 77: pages 3370–3380, 1997 
- Pinel, John P.J. (2011). Biopsychology (8th ed. ed.). Boston: Allyn & Bacon. p. 181. ISBN 978-0-205-83256-9.
- Price, D. D. (9 June 2000). "Psychological and Neural Mechanisms of the Affective Dimension of Pain". Science 288 (5472): 1769–1772. doi:10.1126/science.288.5472.1769.
- Bush G, Frazier JA, Rauch SL, et al. (June 1999). "Anterior cingulate cortex dysfunction in attention-deficit/hyperactivity disorder revealed by fMRI and the Counting Stroop". Biol. Psychiatry 45 (12): 1542–52. doi:10.1016/S0006-3223(99)00083-9. PMID 10376114.
- Pittenger C, Bloch M, Wegner R, Teitelbaum C, Krystal JH, Coric V (2006). "Glutamatergic Dysfunction in Obsessive-Compulsive Disorder and the Potential Clinical Utility of Glutamate-Modulating Agents". Primary Psychiatry 13 (10): 65–77.
- Radua, Joaquim; Mataix-Cols, David (November 2009). "Voxel-wise meta-analysis of grey matter changes in obsessive–compulsive disorder". British Journal of Psychiatry 195 (5): 393–402. doi:10.1192/bjp.bp.108.055046. PMID 19880927.
- Radua, Joaquim; van den Heuvel, Odile A.; Surguladze, Simon; Mataix-Cols, David (5 July 2010). "Meta-analytical comparison of voxel-based morphometry studies in obsessive-compulsive disorder vs other anxiety disorders". Archives of General Psychiatry 67 (7): 701–711. doi:10.1001/archgenpsychiatry.2010.70. PMID 20603451.
- Hamani C, Mayberg H, Stone S, Laxton A, Haber S, Lozano AM. (15 February 2011). "The subcallosal cingulate gyrus in the context of major depression". Biological Psychiatry 69 (4): 301–309. doi:10.1016/j.biopsych.2010.09.034. PMID 21145043.
- Cecil KM, Brubaker CJ, Adler CM, et al. (May 2008). "Decreased brain volume in adults with childhood lead exposure". In Balmes, John. PLoS Med. 5 (5): e112. doi:10.1371/journal.pmed.0050112. PMC 2689675. PMID 18507499.
- Peter Mundy (2003). "Annotation: The neural basis of social impairments in autism: the role of the dorsal medial-frontal cortex and anterior cingulate system". Journal of Child Psychology and Psychiatry 44 (6): 793–809. doi:10.1111/1469-7610.00165.