The community takes its name from Antioch, Turkey, an ancient city in Anatolia. As recently as the 1960s Antioch was a small community catering to the needs of area farmers with amenities such as a feed mill. Adjacent to Bakertown (a similar small community) it was located on the banks of Mill Creek, a minor tributary of the Cumberland River that rises near Nolensville, several miles to the southeast. This area has become less important over time as zoning restrictions forbidding further development on a floodplain have limited the construction of more businesses in this area, which had started to become congested.[original research?]
In the 1970s Antioch experienced explosive growth, largely due to the expansion of the Nashville sewer system to the area and the availability of large amounts of former farmland, which made possible the construction of many low-rise apartment complexes, and several mobile home communities. The area continues to experience some of the highest growth rates in Nashville-Davidson County.
The most important business concentration in Antioch was Hickory Hollow Mall, which opened in 1978 and closed in 2012. It is a regional shopping mall with a gross leasing area of 1,107,476 sq ft (102,887.9 m2), more than 140 stores, and 5,795 parking spaces. Anchor stores include Sears, and Macy's. As of late 2008, the mall had seen an increase in store closures, including larger stores such as Dillard's and Linens 'n Things.[not in citation given] A Walmart Supercenter and many new strip malls have also opened in the area. Large-scale home builders such as Beazer and Centex Homes have constructed many new subdivisions. As of February 2013, Target left the Antioch area.
Starwood Amphitheatre, Nashville's former primary outdoor music venue, was located a few miles south of Antioch on the Rutherford County line. The amphitheatre was closed prior to the 2007 season, and has since been demolished.