Early years 
Singer was born in Camberwell in London, where his father Simeon Singer was a minister and Hebraist. He was educated at City of London School, University College London, and Magdalen College, Oxford (Zoology 1896-99, Honorary Fellow 1953). Trained in zoology and medicine, he qualified for medical practice in 1903. On the day when his medical qualification was announced he was appointed medical officer on an expedition led by Sir John Harrington to the border region between Abyssinia and Sudan. He returned to England and took a position at Sussex County Hospital in Brighton, and in 1907 left for Singapore. Forced to return to England on his father's death in 1908, he held positions at various hospitals in London until he moved to Oxford in 1914 to work with Sir William Osler (first Baronet), then Regius Professor of Medicine at the university.
Later years 
Singer was married in July 1910 to Dorothea Waley Cohen, distinguished in her own right as an historian of the Medieval period. She provided valuable assistance in his publications for the remainder of his life. In the period leading up to World War I, Singer published several monographs, for which he was awarded the D.Litt. degree by Oxford.
Singer accepted a commission as medical officer in the British Army in 1916, first as a pathologist and then as part of an archeological expedition. At war's end, he returned to Oxford to lecture on the history of biology. In 1920 he was appointed to a lectureship in the history of medicine at University College of the University of London. His reputation extended beyond England, and in 1929 he accepted an invitation to lecture at Johns Hopkins University to be conducted the following year. Johns Hopkins was also interested in offering him a permanent post, but their delay allowed the University of London to award him an honorary chair, which he accepted. By the time Johns Hopkins made their formal offer, he was satisfied with his position in London and declined their offer. The Singers spent time in Berkeley where Charles spent three months as a visiting lecturer at the University of California, after which they returned home to London. He was invited again by the University of California at Berkeley to lecture in 1932, an occasion that the Singers used to circle the globe going westward, spending about sixteen months away from England. On their return, Singer resumed his post at UCL, where he remained until his retirement in 1942. His last great publication before retirement was A Short History of Scientific Ideas to 1900.
Singer was one of the two contributors to the revised and updated version for Encyclopædia Britannica of the bulk of Thomas Clifford Allbutt's article Medicine which had been in the 11th edition. As revised for the 14th edition Singer's part was Medicine, History of (in volume 15), which followed after Sir Humphry Rolleston's Medicine, General.
Retirement was not idle for the Singers. Charles continued research into various topics and published several noteworthy books, including editing the monumental A History of Technology, which was released in five volumes between 1954 and 1958, Galen on Anatomical Procedures, and A History of Biology. Numerous articles were also published in this period, some of which remain important. He died in Par, Cornwall.
Award and recognitions 
Charles Singer's life was complemented by numerous awards, honors, and positions of leadership. Among these were an honorary degree (D.Sc.) from Oxford, the Sarton Medal from the History of Science Society, and terms of presidency of several societies, including the British Society of the History of Medicine (1946-1948) and the International Union for the History of Science (1947). He was also a member of the International Society for the History of Medicine.
Partial bibliography 
- From Magic to Science: Essays on the Scientific Twilight (1928)
- A Short History of Science to the Nineteenth Century (1941)
- As editor, A History of Technology (5 vols, between 1954 and 1958), together with Eric John Holmyard and A.R. Hall.
- Galen on Anatomical Procedures (1956)
- A History of Biology to About the Year 1900 (1959)
- Greek Biology & Greek Medicine, Chapters in the History of Science, Clarendon Press, 1922.
- Melvin Kranzberg, Charles Singer and "A History of Technology". Vol. 1, No. 4, Review Issue: A History of Technology (Autumn, 1960), pp. 299-302. doi 10.2307/3101190
- Geoffrey Cantor, 'Presidential Address: Charles Singer and the early years of the British Society for the History of Science', The British Journal for the History of Science 30 (1997), 5-23. doi 10.1017/S0007087496002865
- A. Rupert Hall, 'Eloge: Charles Joseph Singer, 1876-1960', Isis 51:4 (1960), 486, 558-560.
- Anna-K. Mayer, "When things don't talk: knowledge and belief in the inter-war humanism of Charles Singer (1876–1960)" in:The British Journal for the History of Science – Volume 38 – Issue 03 – September 2005. doi 10.1017/S0007087405007004
- Robert T. Gunther and A. V. Simcock, Robert T. Gunther and the Old Ashmolean Museum of the History of Science, Oxford (1985), p. 68.
- 2001, Franz-Andre Sondervorst, Chronique de SIHM