David Chilton Phillips
|David Chilton Phillips|
|Born||7 March 1924|
|Died||23 February 1999(aged 74)|
|Other notable students||Janet Thornton (postdoc)|
|Known for||Discovering structure of lysozyme|
Phillips was the first person to determine in atomic detail the structure of the enzyme lysozyme, which he did in the Davy Faraday Research Laboratories of the Royal Institution in London in 1965. Lysozyme, which was discovered in 1922 by Alexander Fleming, is found in tear drops, nasal mucus, gastric secretions and egg white. Lysozyme exhibits some antibacterial activity so that the discovery of its structure and mode of action were key scientific objectives. David Phillips solved the structure of lysozyme and also explained the mechanism of its action in destroying certain bacteria by a brilliant application of the technique of X-ray crystallography, a technique to which he had been introduced as a PhD student at the University in Cardiff, and to which he later made major instrumental contributions.
Education and Career
David Chilton Phillips, the son of a tailor and Methodist preacher, was born in Ellesmere, Shropshire which gave rise to his title Baron Phillips of Ellesmere. He was educated at Oswestry Boy's High School and then at the University College of South Wales and Monmouth where he studied physics, electrical engineering, and mathematics. His degree was interrupted between 1944 and 1947 for service in the Royal Navy as a radar officer on HMS Illustrious. He returned to Cardiff to complete his degree and subsequently undertook postgraduate studies with Professor Arthur J. C. Wilson, a noted X-ray crystal physicist. After a brief postdoctoral period at the National Research Council in Ottawa (1951–55) he joined the Royal Institution. In 1968 he became the Professor of Molecular Biophysics in the Department of Zoology at the University of Oxford where he remained until his retirement in 1985. During that time he became a Fellow of the Royal Society and then its Biological Secretary from 1976 to 1983.
David was made Knight Bachelor in 1979, invested as Knight Commander of the Order of the British Empire (KBE) in 1989, and appointed in 1994 as a Life Peer as Baron Phillips of Ellesmere. In the House of Lords, he chaired the select committee on Science and Technology and he is credited with getting Parliament onto the World Wide Web. In 1994, he was awarded an Honorary Degree (Doctor of Science) by the University of Bath.
In 1980 he was invited to deliver the Royal Institution Christmas Lecture on The Chicken, the Egg and the Molecules.
Lord Phillips died of cancer, on 23 February 1999.
- Sternberg, Michael Joseph Ezra (1977). Studies of protein conformation (DPhil thesis). University of Oxford.
- Phillips, D. C.; Sternberg, M. J.; Thornton, J. M.; Wilson, I. A. (1978). "An analysis of the structure of triose phosphate isomerase and its comparison with lactate dehydrogenase". Journal of molecular biology 119 (2): 329–51. PMID 633372.
- Phillips, D. C.; Rivers, P. S.; Sternberg, M. J.; Thornton, J. M.; Wilson, I. A. (1977). "An analysis of the three-dimensional structure of chicken triose phosphate isomerase". Biochemical Society transactions 5 (3): 642–7. PMID 902882.
- Johnson, L. N. (2000). "David Chilton Phillips, Lord Phillips of Ellesmere, K.B.E. 7 March 1924 -- 23 February 1999: Elected F.R.S. 1967". Biographical Memoirs of Fellows of the Royal Society 46: 377–310. doi:10.1098/rsbm.1999.0092.
- Fleming, A. (1922). "On a Remarkable Bacteriolytic Element Found in Tissues and Secretions". Proceedings of the Royal Society B: Biological Sciences 93 (653): 306. doi:10.1098/rspb.1922.0023.
- "Honorary Graduates 1989 to present". bath.ac.uk. University of Bath. Retrieved 18 February 2012.
- Cardiff Scientific Society by John Griffith (Chair) and Bruce Etherington (Vice Chair)
Max Ferdinand Perutz
|Fullerian Professor of Physiology
John Bertrand Gurdon