A dehydrogenase (also called DHO in the literature) is an enzyme belonging to the group of Oxidoreductases that oxidizes a substrate by a reduction reaction that transfers one or more hydrides (H−) to an electron acceptor, usually NAD+/NADP+ or a flavin coenzyme such as FAD or FMN.
- aldehyde dehydrogenase
- acetaldehyde dehydrogenase
- alcohol dehydrogenase
- glutamate dehydrogenase (an enzyme that can convert glutamate to α-Ketoglutarate and vice versa).
- lactate dehydrogenase
- pyruvate dehydrogenase (a common enzyme that feeds the TCA Cycle in converting Pyruvate to Acetyl CoA)
- glucose-6-phosphate dehydrogenase (involved in the pentose phosphate pathway)
- glyceraldehyde-3-phosphate dehydrogenase (involved in glycolysis)
- sorbitol dehydrogenase
TCA cycle examples:
- isocitrate dehydrogenase
- alpha-ketoglutarate dehydrogenase
- succinate dehydrogenase
- malate dehydrogenase.
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