Dehydrogenase

A dehydrogenase (also called DHO in the literature) is an enzyme that oxidises a substrate by a reduction reaction that transfers one or more hydrides (H⁻) to an electron acceptor, usually NAD⁺/NADP⁺ or a flavin coenzyme such as FAD or FMN.

Examples

• aldehyde dehydrogenase
• acetaldehyde dehydrogenase
• alcohol dehydrogenase
• glutamate dehydrogenase (an enzyme that can convert glutamate to α-Ketoglutarate and vice versa).
• lactate dehydrogenase
• pyruvate dehydrogenase (a common enzyme that feeds the TCA Cycle in converting Pyruvate to Acetyl CoA)
• glucose-6-phosphate dehydrogenase (involved in the pentose phosphate pathway)
• glyceraldehyde-3-phosphate dehydrogenase (involved in glycolysis)
• sorbitol dehydrogenase

TCA cycle examples:

• isocitrate dehydrogenase
• alpha-ketoglutarate dehydrogenase
• succinate dehydrogenase
• malate dehydrogenase

External links

• Dehydrogenase at eMedicine Dictionary