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Eukaryotic translation elongation factor 1 gamma
Protein EEF1G PDB 1pbu.png
PDB rendering based on 1pbu.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EEF1G ; EF1G; GIG35
External IDs OMIM130593 MGI1914410 HomoloGene20363 GeneCards: EEF1G Gene
Species Human Mouse
Entrez 1937 67160
Ensembl ENSG00000254772 ENSMUSG00000071644
UniProt P26641 Q9D8N0
RefSeq (mRNA) NM_001404 NM_026007
RefSeq (protein) NP_001395 NP_080283
Location (UCSC) Chr 11:
62.33 – 62.34 Mb
Chr 19:
8.97 – 8.98 Mb
PubMed search [1] [2]

Elongation factor 1-gamma is a protein that in humans is encoded by the EEF1G gene.[1][2][3]

This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit contains an N-terminal glutathione transferase domain, which may be involved in regulating the assembly of multisubunit complexes containing this elongation factor and aminoacyl-tRNA synthetases.[3]


EEF1G has been shown to interact with RECQL5,[4] EEF1B2,[4][5] EEF1D,[4][5] LZTS1,[6] HARS[7] and Leucyl-tRNA synthetase.[7]


  1. ^ Kumabe T, Sohma Y, Yamamoto T (July 1992). "Human cDNAs encoding elongation factor 1 gamma and the ribosomal protein L19". Nucleic Acids Res 20 (10): 2598. doi:10.1093/nar/20.10.2598. PMC 312399. PMID 1598220. 
  2. ^ Sanders J, Maassen JA, Moller W (January 1993). "Elongation factor-1 messenger-RNA levels in cultured cells are high compared to tissue and are not drastically affected further by oncogenic transformation". Nucleic Acids Res 20 (22): 5907–10. doi:10.1093/nar/20.22.5907. PMC 334453. PMID 1461723. 
  3. ^ a b "Entrez Gene: EEF1G eukaryotic translation elongation factor 1 gamma". 
  4. ^ a b c Stelzl, Ulrich; Worm Uwe, Lalowski Maciej, Haenig Christian, Brembeck Felix H, Goehler Heike, Stroedicke Martin, Zenkner Martina, Schoenherr Anke, Koeppen Susanne, Timm Jan, Mintzlaff Sascha, Abraham Claudia, Bock Nicole, Kietzmann Silvia, Goedde Astrid, Toksöz Engin, Droege Anja, Krobitsch Sylvia, Korn Bernhard, Birchmeier Walter, Lehrach Hans, Wanker Erich E (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell (United States) 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. ISSN 0092-8674. PMID 16169070. 
  5. ^ a b Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  6. ^ Ishii, H; Vecchione A; Murakumo Y; Baldassarre G; Numata S; Trapasso F; Alder H; Baffa R; Croce C M (August 2001). "FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (18): 10374–9. doi:10.1073/pnas.181222898. ISSN 0027-8424. PMC 56968. PMID 11504921. 
  7. ^ a b Sang Lee, Jong; Gyu Park Sang; Park Heonyong; Seol Wongi; Lee Sangwon; Kim Sunghoon (February 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochem. Biophys. Res. Commun. (United States) 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. ISSN 0006-291X. PMID 11829477. 

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