For his career, he batted .238 with 39 HR, 174 RBI, and 126 runs scored in 554 games.
His son, Scott Spiezio, is a former Major League player with the Angels, Mariners, Cardinals,and Braves. The two are the third father-son tandem in Cardinals' history. Both of the Spiezios have won World Championships. Ed Spiezio won one with the St. Louis Cardinals (1967), while Scott won in 2002 with the Anaheim Angels and in 2006 with the Cardinals.