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Fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
Protein FIS1 PDB 1iyg.png
PDB rendering based on 1iyg.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FIS1 ; TTC11
External IDs OMIM609003 MGI1913687 HomoloGene41099 GeneCards: FIS1 Gene
Species Human Mouse
Entrez 51024 66437
Ensembl ENSG00000214253 ENSMUSG00000019054
UniProt Q9Y3D6 Q9CQ92
RefSeq (mRNA) NM_016068 NM_001163243
RefSeq (protein) NP_057152 NP_001156715
Location (UCSC) Chr 7:
100.88 – 100.9 Mb
Chr 5:
136.95 – 136.97 Mb
PubMed search [1] [2]

Mitochondrial fission 1 protein is a protein that in humans is encoded by the FIS1 gene.[1][2][3]

The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003).[supplied by OMIM][3]


FIS1 has been shown to interact with DNM1L.[4]


  1. ^ Stojanovski D, Koutsopoulos OS, Okamoto K, Ryan MT (March 2004). "Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology". J Cell Sci 117 (Pt 7): 1201–10. doi:10.1242/jcs.01058. PMID 14996942. 
  2. ^ Kong D, Xu L, Yu Y, Zhu W, Andrews DW, Yoon Y, Kuo TH (July 2005). "Regulation of Ca2+-induced permeability transition by Bcl-2 is antagonized by Drpl and hFis1". Mol Cell Biochem 272 (1–2): 187–99. doi:10.1007/s11010-005-7323-3. PMID 16010987. 
  3. ^ a b "Entrez Gene: FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)". 
  4. ^ Yoon, Yisang; Krueger Eugene W; Oswald Barbara J; McNiven Mark A (August 2003). "The Mitochondrial Protein hFis1 Regulates Mitochondrial Fission in Mammalian Cells through an Interaction with the Dynamin-Like Protein DLP1". Mol. Cell. Biol. (United States) 23 (15): 5409–20. doi:10.1128/MCB.23.15.5409-5420.2003. ISSN 0270-7306. PMC 165727. PMID 12861026. 

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