In addition to missions featuring the whole team, there are various solo missions during the game, such as the Human Torch chasing the Silver Surfer through New York and Sue Storm using her invisibility powers to sneak through a Military Base.
The game also allows the use of fused attacks, giving you the ability of combining powers to pull off new moves. There are 12 different moves in the game, one with each combination of team members. One example is Sue creating an energy field & Johnny filling it with flame, effectively creating a bomb. Another is Ben charging toward enemy hordes and Sue projecting spinning telekinetic blades around him.