GAS6

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Growth arrest-specific 6
Protein GAS6 PDB 1h30.png
PDB rendering based on 1h30.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols GAS6 ; AXLLG; AXSF
External IDs OMIM600441 MGI95660 HomoloGene638 GeneCards: GAS6 Gene
Orthologs
Species Human Mouse
Entrez 2621 14456
Ensembl ENSG00000183087 ENSMUSG00000031451
UniProt Q14393 Q61592
RefSeq (mRNA) NM_000820 NM_019521
RefSeq (protein) NP_000811 NP_062394
Location (UCSC) Chr 13:
114.52 – 114.57 Mb
Chr 8:
13.47 – 13.49 Mb
PubMed search [1] [2]

Growth arrest-specific 6, also known as GAS6, is a human gene coding for the Gas6 protein. It is similar to the Protein S with the same domain organization and 43% amino acid identity. It was originally found as a gene upregulated by growth arrested fibroblasts.

GAS6 is a gamma-carboxyglutamic acid (Gla) domain-containing protein thought to be involved in the stimulation of cell proliferation[1] The presence of Gla needs a vitamin K-dependent enzymatic reaction that carboxylates the gamma carbon of certain glutamic residues of the protein during its production in the endoplasmic reticulum.

Interactions[edit]

GAS6 has been shown to interact with AXL receptor tyrosine kinase, MerTK and TYRO3.[2][3]

References[edit]

  1. ^ "Entrez Gene: GAS6 growth arrest-specific 6". 
  2. ^ Mark, M R; Chen J; Hammonds R G; Sadick M; Godowsk P J (Apr 1996). "Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl". J. Biol. Chem. (UNITED STATES) 271 (16): 9785–9. doi:10.1074/jbc.271.16.9785. ISSN 0021-9258. PMID 8621659. 
  3. ^ Nagata, K; Ohashi K; Nakano T; Arita H; Zong C; Hanafusa H; Mizuno K (Nov 1996). "Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases". J. Biol. Chem. (UNITED STATES) 271 (47): 30022–7. doi:10.1074/jbc.271.47.30022. ISSN 0021-9258. PMID 8939948. 

Further reading[edit]