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Growth arrest-specific 6
Protein GAS6 PDB 1h30.png
PDB rendering based on 1h30.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols GAS6 ; AXLLG; AXSF
External IDs OMIM600441 MGI95660 HomoloGene638 GeneCards: GAS6 Gene
Species Human Mouse
Entrez 2621 14456
Ensembl ENSG00000183087 ENSMUSG00000031451
UniProt Q14393 Q61592
RefSeq (mRNA) NM_000820 NM_019521
RefSeq (protein) NP_000811 NP_062394
Location (UCSC) Chr 13:
113.82 – 113.86 Mb
Chr 8:
13.47 – 13.49 Mb
PubMed search [1] [2]

Growth arrest-specific 6, also known as GAS6, is a human gene coding for the Gas6 protein. It is similar to the Protein S with the same domain organization and 43% amino acid identity. It was originally found as a gene upregulated by growth arrested fibroblasts.

GAS6 is a gamma-carboxyglutamic acid (Gla) domain-containing protein thought to be involved in the stimulation of cell proliferation[1] The presence of Gla needs a vitamin K-dependent enzymatic reaction that carboxylates the gamma carbon of certain glutamic residues of the protein during its production in the endoplasmic reticulum.


GAS6 has been shown to interact with AXL receptor tyrosine kinase, MerTK and TYRO3.[2][3]


  1. ^ "Entrez Gene: GAS6 growth arrest-specific 6". 
  2. ^ Mark, M R; Chen J; Hammonds R G; Sadick M; Godowsk P J (Apr 1996). "Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl". J. Biol. Chem. (UNITED STATES) 271 (16): 9785–9. doi:10.1074/jbc.271.16.9785. ISSN 0021-9258. PMID 8621659. 
  3. ^ Nagata, K; Ohashi K; Nakano T; Arita H; Zong C; Hanafusa H; Mizuno K (Nov 1996). "Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases". J. Biol. Chem. (UNITED STATES) 271 (47): 30022–7. doi:10.1074/jbc.271.47.30022. ISSN 0021-9258. PMID 8939948. 

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