AXL receptor tyrosine kinase

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AXL receptor tyrosine kinase

PDB rendering based on 2c5d.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols AXL ; JTK11; UFO
External IDs OMIM109135 MGI1347244 HomoloGene7583 ChEMBL: 4895 GeneCards: AXL Gene
EC number 2.7.10.1
RNA expression pattern
PBB GE AXL 202686 s at tn.png
PBB GE AXL 202685 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 558 26362
Ensembl ENSG00000167601 ENSMUSG00000002602
UniProt P30530 Q00993
RefSeq (mRNA) NM_001699 NM_001190974
RefSeq (protein) NP_001690 NP_001177903
Location (UCSC) Chr 19:
41.73 – 41.77 Mb
Chr 7:
25.76 – 25.79 Mb
PubMed search [1] [2]

Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene. [1][2]

Function[edit]

The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, the Axl protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation. This receptor can also mediate cell aggregation by homophilic binding. Axl is a chronic myelogenous leukemia-associated oncogene and also associated with colon cancer and melanoma. It is in close vicinity to the bcl3 oncogene, which is at 19q13.1-q13.2. The Axl gene is evolutionarily conserved between vertebrate species. This gene has two different alternatively spliced transcript variants.[2]

Interactions[edit]

AXL receptor tyrosine kinase has been shown to interact with TENC1.[3] Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival.[4]

References[edit]

  1. ^ O'Bryan JP, Frye RA, Cogswell PC, Neubauer A, Kitch B, Prokop C, Espinosa R 3rd, Le Beau MM, Earp HS, Liu ET (Oct 1991). "axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase". Mol Cell Biol 11 (10): 5016–31. PMC 361494. PMID 1656220. 
  2. ^ a b "Entrez Gene: AXL AXL receptor tyrosine kinase". 
  3. ^ Hafizi S, Alindri F, Karlsson R, Dahlbäck B (2002). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem. Biophys. Res. Commun. 299 (5): 793–800. doi:10.1016/S0006-291X(02)02718-3. PMID 12470648. 
  4. ^ Vajkoczy P, Knyazev P, Kunkel A, Capelle HH, Behrndt S, von Tengg-Kobligk H, Kiessling F, Eichelsbacher U, Essig M, Read TA, Erber R, Ullrich A (2006). "Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival". Proc. Natl. Acad. Sci. U.S.A. 103 (15): 5799–804. doi:10.1073/pnas.0510923103. PMC 1458653. PMID 16585512. 

Further reading[edit]