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TYRO3 protein tyrosine kinase
Protein TYRO3 PDB 1rhf.png
PDB rendering based on 1rhf.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TYRO3 ; BYK; Dtk; RSE; Sky; Tif
External IDs OMIM600341 MGI104294 HomoloGene4585 ChEMBL: 5314 GeneCards: TYRO3 Gene
EC number
RNA expression pattern
PBB GE TYRO3 211432 s at tn.png
PBB GE TYRO3 211431 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7301 22174
Ensembl ENSG00000092445 ENSMUSG00000027298
UniProt Q06418 P55144
RefSeq (mRNA) NM_006293 NM_001290800
RefSeq (protein) NP_006284 NP_001277729
Location (UCSC) Chr 15:
41.85 – 41.87 Mb
Chr 2:
119.8 – 119.82 Mb
PubMed search [1] [2]

Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the TYRO3 gene.[1][2]


TYRO3 has been shown to interact with PIK3R1[3] and GAS6.[4][5]


  1. ^ Richard I, Broux O, Chiannilkulchai N, Fougerousse F, Allamand V, Bourg N, Brenguier L, Devaud C, Pasturaud P (March 1995). "Regional localization of human chromosome 15 loci". Genomics 23 (3): 619–27. doi:10.1006/geno.1994.1550. PMID 7851890. 
  2. ^ "Entrez Gene: TYRO3 TYRO3 protein tyrosine kinase". 
  3. ^ Lan, Z; Wu H; Li W; Wu S; Lu L; Xu M; Dai W (January 2000). "Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway". Blood (UNITED STATES) 95 (2): 633–8. ISSN 0006-4971. PMID 10627473. 
  4. ^ Mark, M R; Chen J; Hammonds R G; Sadick M; Godowsk P J (April 1996). "Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl". J. Biol. Chem. (UNITED STATES) 271 (16): 9785–9. doi:10.1074/jbc.271.16.9785. ISSN 0021-9258. PMID 8621659. 
  5. ^ Nagata, K; Ohashi K; Nakano T; Arita H; Zong C; Hanafusa H; Mizuno K (November 1996). "Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases". J. Biol. Chem. (UNITED STATES) 271 (47): 30022–7. doi:10.1074/jbc.271.47.30022. ISSN 0021-9258. PMID 8939948. 

Further reading[edit]