TYRO3

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TYRO3 protein tyrosine kinase
Protein TYRO3 PDB 1rhf.png
PDB rendering based on 1rhf.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TYRO3 ; BYK; Dtk; RSE; Sky; Tif
External IDs OMIM600341 MGI104294 HomoloGene4585 ChEMBL: 5314 GeneCards: TYRO3 Gene
EC number 2.7.10.1
RNA expression pattern
PBB GE TYRO3 211432 s at tn.png
PBB GE TYRO3 211431 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7301 22174
Ensembl ENSG00000092445 ENSMUSG00000027298
UniProt Q06418 P55144
RefSeq (mRNA) NM_006293 NM_001290800
RefSeq (protein) NP_006284 NP_001277729
Location (UCSC) Chr 15:
41.85 – 41.87 Mb
Chr 2:
119.8 – 119.82 Mb
PubMed search [1] [2]

Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the TYRO3 gene.[1][2]

Interactions[edit]

TYRO3 has been shown to interact with:

References[edit]

  1. ^ Richard I, Broux O, Chiannilkulchai N, Fougerousse F, Allamand V, Bourg N et al. (March 1995). "Regional localization of human chromosome 15 loci". Genomics 23 (3): 619–27. doi:10.1006/geno.1994.1550. PMID 7851890. 
  2. ^ "Entrez Gene: TYRO3 TYRO3 protein tyrosine kinase". 
  3. ^ Mark M, Chen J, Hammonds R, Sadick M, Godowsk P (April 1996). "Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl". J. Biol. Chem. 271 (16): 9785–9. PMID 8621659. 
  4. ^ Nagata K, Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H et al. (November 1996). "Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases". J. Biol. Chem. 271 (47): 30022–7. PMID 8939948. 
  5. ^ Lan Z, Wu H, Li W, Wu S, Lu L, Xu M et al. (January 2000). "Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway". Blood 95 (2): 633–8. PMID 10627473. 

Further reading[edit]

  • Mark M, Scadden D, Wang Z, Gu Q, Goddard A, Godowski P (1994). "rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain". J. Biol. Chem. 269 (14): 10720–8. PMID 7511603. 
  • Toshima J, Ohashi K, Iwashita S, Mizuno K (1995). "Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase". Biochem. Biophys. Res. Commun. 209 (2): 656–63. doi:10.1006/bbrc.1995.1549. PMID 7537495. 
  • Crosier K, Hall L, Lewis P, Morris C, Wood C, Morris J et al. (1995). "Isolation and characterization of the human DTK receptor tyrosine kinase". Growth Factors 11 (2): 137–44. doi:10.3109/08977199409001055. PMID 7857658. 
  • Ohashi K, Mizuno K, Kuma K, Miyata T, Nakamura T (1994). "Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain". Oncogene 9 (3): 699–705. PMID 8108112. 
  • Dai W, Pan H, Hassanain H, Gupta S, Murphy M (1994). "Molecular cloning of a novel receptor tyrosine kinase, tif, highly expressed in human ovary and testis". Oncogene 9 (3): 975–9. PMID 8108143. 
  • Polvi A, Armstrong E, Lai C, Lemke G, Huebner K, Spritz R et al. (1994). "The human TYRO3 gene and pseudogene are located in chromosome 15q14-q25". Gene 134 (2): 289–93. doi:10.1016/0378-1119(93)90109-G. PMID 8262388. 
  • Mark M, Chen J, Hammonds R, Sadick M, Godowsk P (1996). "Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl". J. Biol. Chem. 271 (16): 9785–9. doi:10.1074/jbc.271.16.9785. PMID 8621659. 
  • Crosier P, Freeman S, Orlic D, Bodine D, Crosier K (1996). "The Dtk receptor tyrosine kinase, which binds protein S, is expressed during hematopoiesis". Exp. Hematol. 24 (2): 318–23. PMID 8641360. 
  • Nagata K, Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H et al. (1997). "Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases". J. Biol. Chem. 271 (47): 30022–7. doi:10.1074/jbc.271.47.30022. PMID 8939948. 
  • Kajii Y, Ninomiya D, Kato M, Mizuguchi M, Saji M, Katsumoto T et al. (1997). "A tyrosine kinase-like molecule is localized in the nuclear membrane of neurons: hippocampal behavior under stress". Biol. Cell 88 (1–2): 45–54. doi:10.1016/S0248-4900(97)86830-X. PMID 9175267. 
  • Lan Z, Wu H, Li W, Wu S, Lu L, Xu M et al. (2000). "Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway". Blood 95 (2): 633–8. PMID 10627473. 
  • Yin J, Hambly B, Bao S, Painter D, Bishop G, Eris J (2004). "Expression of growth arrest-specific gene 6 and its receptors in dysfunctional human renal allografts". Transpl. Int. 16 (9): 681–8. doi:10.1007/s00147-003-0593-3. PMID 12768229. 
  • Heiring C, Dahlbäck B, Muller Y (2004). "Ligand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase family". J. Biol. Chem. 279 (8): 6952–8. doi:10.1074/jbc.M311750200. PMID 14623883. 
  • Gould W, Baxi S, Schroeder R, Peng Y, Leadley R, Peterson J et al. (2005). "Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses". J. Thromb. Haemost. 3 (4): 733–41. doi:10.1111/j.1538-7836.2005.01186.x. PMID 15733062. 
  • Hafizi S, Gustafsson A, Stenhoff J, Dahlbäck B (2005). "The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases". Int. J. Biochem. Cell Biol. 37 (11): 2344–56. doi:10.1016/j.biocel.2005.05.006. PMID 15964779. 
  • Shimojima M, Takada A, Ebihara H, Neumann G, Fujioka K, Irimura T et al. (2006). "Tyro3 Family-Mediated Cell Entry of Ebola and Marburg Viruses". J. Virol. 80 (20): 10109–16. doi:10.1128/JVI.01157-06. PMC 1617303. PMID 17005688.