TYRO3

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TYRO3 protein tyrosine kinase
Protein TYRO3 PDB 1rhf.png
PDB rendering based on 1rhf.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TYRO3 ; BYK; Dtk; RSE; Sky; Tif
External IDs OMIM600341 MGI104294 HomoloGene4585 IUPHAR: 1836 ChEMBL: 5314 GeneCards: TYRO3 Gene
EC number 2.7.10.1
RNA expression pattern
PBB GE TYRO3 211432 s at tn.png
PBB GE TYRO3 211431 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7301 22174
Ensembl ENSG00000092445 ENSMUSG00000027298
UniProt Q06418 P55144
RefSeq (mRNA) NM_006293 NM_001290800
RefSeq (protein) NP_006284 NP_001277729
Location (UCSC) Chr 15:
41.85 – 41.87 Mb
Chr 2:
119.8 – 119.82 Mb
PubMed search [1] [2]

Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the TYRO3 gene.[1][2]

Interactions[edit]

TYRO3 has been shown to interact with:

References[edit]

  1. ^ Richard I, Broux O, Chiannilkulchai N, Fougerousse F, Allamand V, Bourg N et al. (March 1995). "Regional localization of human chromosome 15 loci". Genomics 23 (3): 619–27. doi:10.1006/geno.1994.1550. PMID 7851890. 
  2. ^ "Entrez Gene: TYRO3 TYRO3 protein tyrosine kinase". 
  3. ^ Mark MR, Chen J, Hammonds RG, Sadick M, Godowsk PJ (April 1996). "Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl". J. Biol. Chem. 271 (16): 9785–9. doi:10.1074/jbc.271.16.9785. PMID 8621659. 
  4. ^ Nagata K, Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H et al. (November 1996). "Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases". J. Biol. Chem. 271 (47): 30022–7. doi:10.1074/jbc.271.47.30022. PMID 8939948. 
  5. ^ Lan Z, Wu H, Li W, Wu S, Lu L, Xu M et al. (January 2000). "Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway". Blood 95 (2): 633–8. PMID 10627473. 

Further reading[edit]

  • Mark MR, Scadden DT, Wang Z, Gu Q, Goddard A, Godowski PJ (1994). "rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain". J. Biol. Chem. 269 (14): 10720–8. PMID 7511603. 
  • Toshima J, Ohashi K, Iwashita S, Mizuno K (1995). "Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase". Biochem. Biophys. Res. Commun. 209 (2): 656–63. doi:10.1006/bbrc.1995.1549. PMID 7537495. 
  • Crosier KE, Hall LR, Lewis PM, Morris CM, Wood CR, Morris JC et al. (1995). "Isolation and characterization of the human DTK receptor tyrosine kinase". Growth Factors 11 (2): 137–44. doi:10.3109/08977199409001055. PMID 7857658. 
  • Ohashi K, Mizuno K, Kuma K, Miyata T, Nakamura T (1994). "Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain". Oncogene 9 (3): 699–705. PMID 8108112. 
  • Dai W, Pan H, Hassanain H, Gupta SL, Murphy MJ (1994). "Molecular cloning of a novel receptor tyrosine kinase, tif, highly expressed in human ovary and testis". Oncogene 9 (3): 975–9. PMID 8108143. 
  • Polvi A, Armstrong E, Lai C, Lemke G, Huebner K, Spritz RA et al. (1994). "The human TYRO3 gene and pseudogene are located in chromosome 15q14-q25". Gene 134 (2): 289–93. doi:10.1016/0378-1119(93)90109-G. PMID 8262388. 
  • Mark MR, Chen J, Hammonds RG, Sadick M, Godowsk PJ (1996). "Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl". J. Biol. Chem. 271 (16): 9785–9. doi:10.1074/jbc.271.16.9785. PMID 8621659. 
  • Crosier PS, Freeman SA, Orlic D, Bodine DM, Crosier KE (1996). "The Dtk receptor tyrosine kinase, which binds protein S, is expressed during hematopoiesis". Exp. Hematol. 24 (2): 318–23. PMID 8641360. 
  • Nagata K, Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H et al. (1997). "Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases". J. Biol. Chem. 271 (47): 30022–7. doi:10.1074/jbc.271.47.30022. PMID 8939948. 
  • Kajii Y, Ninomiya D, Kato M, Mizuguchi M, Saji M, Katsumoto T et al. (1997). "A tyrosine kinase-like molecule is localized in the nuclear membrane of neurons: hippocampal behavior under stress". Biol. Cell 88 (1–2): 45–54. doi:10.1016/S0248-4900(97)86830-X. PMID 9175267. 
  • Lan Z, Wu H, Li W, Wu S, Lu L, Xu M et al. (2000). "Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway". Blood 95 (2): 633–8. PMID 10627473. 
  • Yin JL, Hambly BD, Bao SS, Painter D, Bishop GA, Eris JM (2004). "Expression of growth arrest-specific gene 6 and its receptors in dysfunctional human renal allografts". Transpl. Int. 16 (9): 681–8. doi:10.1007/s00147-003-0593-3. PMID 12768229. 
  • Heiring C, Dahlbäck B, Muller YA (2004). "Ligand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase family". J. Biol. Chem. 279 (8): 6952–8. doi:10.1074/jbc.M311750200. PMID 14623883. 
  • Gould WR, Baxi SM, Schroeder R, Peng YW, Leadley RJ, Peterson JT et al. (2005). "Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses". J. Thromb. Haemost. 3 (4): 733–41. doi:10.1111/j.1538-7836.2005.01186.x. PMID 15733062. 
  • Hafizi S, Gustafsson A, Stenhoff J, Dahlbäck B (2005). "The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases". Int. J. Biochem. Cell Biol. 37 (11): 2344–56. doi:10.1016/j.biocel.2005.05.006. PMID 15964779. 
  • Shimojima M, Takada A, Ebihara H, Neumann G, Fujioka K, Irimura T et al. (2006). "Tyro3 Family-Mediated Cell Entry of Ebola and Marburg Viruses". J. Virol. 80 (20): 10109–16. doi:10.1128/JVI.01157-06. PMC 1617303. PMID 17005688.