TYRO3

TYRO3 protein tyrosine kinase
PDB rendering based on 1rhf.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1RHF
Identifiers
Symbols	TYRO3; BYK; Dtk; RSE; Sky; Tif
External IDs	OMIM: 600341 MGI: 104294 HomoloGene: 4585 ChEMBL: 5314 GeneCards: TYRO3 Gene
EC number	2.7.10.1
Gene Ontology Molecular function • protein tyrosine kinase activity • transmembrane receptor protein tyrosine kinase activity • receptor signaling protein tyrosine kinase activity • protein binding • ATP binding • phosphatidylinositol 3-kinase binding • protein heterodimerization activity Cellular component • nucleus • nuclear envelope • endoplasmic reticulum membrane • integral to plasma membrane Biological process • natural killer cell differentiation • cell adhesion • signal transduction • spermatogenesis • phosphatidylinositol 3-kinase cascade • forebrain cell migration • signal transduction by phosphorylation • platelet activation • secretion by cell • negative regulation of toll-like receptor signaling pathway • substrate adhesion-dependent cell spreading • ovulation cycle • apoptotic cell clearance • protein kinase B signaling cascade • negative regulation of neuron apoptotic process • negative regulation of innate immune response • protein autophosphorylation • negative regulation of inflammatory response • negative regulation of lymphocyte activation • vagina development • neuron homeostasis • platelet aggregation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7301	22174
Ensembl	ENSG00000092445	ENSMUSG00000027298
UniProt	Q06418	P55144
RefSeq (mRNA)	NM_006293	NM_019392
RefSeq (protein)	NP_006284	NP_062265
Location (UCSC)	Chr 15: 41.85 – 41.87 Mb	Chr 2: 119.8 – 119.82 Mb
PubMed search	[1]	[2]

Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the TYRO3 gene.

Interactions

TYRO3 has been shown to interact with PIK3R1 and GAS6.

Further reading

• Mark MR, Scadden DT, Wang Z et al. (1994). "rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain". J. Biol. Chem. 269 (14): 10720–8. PMID 7511603. 
• Toshima J, Ohashi K, Iwashita S, Mizuno K (1995). "Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase". Biochem. Biophys. Res. Commun. 209 (2): 656–63. doi:10.1006/bbrc.1995.1549. PMID 7537495. 
• Crosier KE, Hall LR, Lewis PM et al. (1995). "Isolation and characterization of the human DTK receptor tyrosine kinase". Growth Factors 11 (2): 137–44. doi:10.3109/08977199409001055. PMID 7857658. 
• Ohashi K, Mizuno K, Kuma K et al. (1994). "Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain". Oncogene 9 (3): 699–705. PMID 8108112. 
• Dai W, Pan H, Hassanain H et al. (1994). "Molecular cloning of a novel receptor tyrosine kinase, tif, highly expressed in human ovary and testis". Oncogene 9 (3): 975–9. PMID 8108143. 
• Polvi A, Armstrong E, Lai C et al. (1994). "The human TYRO3 gene and pseudogene are located in chromosome 15q14-q25". Gene 134 (2): 289–93. doi:10.1016/0378-1119(93)90109-G. PMID 8262388. 
• Mark MR, Chen J, Hammonds RG et al. (1996). "Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl". J. Biol. Chem. 271 (16): 9785–9. doi:10.1074/jbc.271.16.9785. PMID 8621659. 
• Crosier PS, Freeman SA, Orlic D et al. (1996). "The Dtk receptor tyrosine kinase, which binds protein S, is expressed during hematopoiesis". Exp. Hematol. 24 (2): 318–23. PMID 8641360. 
• Nagata K, Ohashi K, Nakano T et al. (1997). "Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases". J. Biol. Chem. 271 (47): 30022–7. doi:10.1074/jbc.271.47.30022. PMID 8939948. 
• Kajii Y, Ninomiya D, Kato M et al. (1997). "A tyrosine kinase-like molecule is localized in the nuclear membrane of neurons: hippocampal behavior under stress". Biol. Cell 88 (1–2): 45–54. doi:10.1016/S0248-4900(97)86830-X. PMID 9175267. 
• Lan Z, Wu H, Li W et al. (2000). "Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway". Blood 95 (2): 633–8. PMID 10627473. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Yin JL, Hambly BD, Bao SS et al. (2004). "Expression of growth arrest-specific gene 6 and its receptors in dysfunctional human renal allografts". Transpl. Int. 16 (9): 681–8. doi:10.1007/s00147-003-0593-3. PMID 12768229. 
• Heiring C, Dahlbäck B, Muller YA (2004). "Ligand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase family". J. Biol. Chem. 279 (8): 6952–8. doi:10.1074/jbc.M311750200. PMID 14623883. 
• Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Gould WR, Baxi SM, Schroeder R et al. (2005). "Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses". J. Thromb. Haemost. 3 (4): 733–41. doi:10.1111/j.1538-7836.2005.01186.x. PMID 15733062. 
• Hafizi S, Gustafsson A, Stenhoff J, Dahlbäck B (2005). "The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases". Int. J. Biochem. Cell Biol. 37 (11): 2344–56. doi:10.1016/j.biocel.2005.05.006. PMID 15964779. 
• Shimojima M, Takada A, Ebihara H et al. (2006). "Tyro3 Family-Mediated Cell Entry of Ebola and Marburg Viruses". J. Virol. 80 (20): 10109–16. doi:10.1128/JVI.01157-06. PMC 1617303. PMID 17005688.