Drakoulias grew up in Syosset, New York and attended Syosset High School where he started his musical career with a band called Lifeline. He went to college at New York University (NYU), where he majored in music and business. There he befriended Rick Rubin, whom he met after he started dating an ex-girlfriend of Rubin's. He became one of the first hires for Rubin's Def Jam label. As an A&R man, he discovered L.L. Cool J and the Beastie Boys. After Rubin left Def Jam to move to Los Angeles and form the Def American label, which was later retitled American Recordings, Drakoulias moved with him and became a producer. Drakoulias signed The Black Crowes, The Jayhawks and The Freewheelers to American Recordings, and produced albums for all three. He has also produced albums for artists including Tom Petty and the Heartbreakers, Maria McKee, Primal Scream, Madrugada and Screaming Trees. He has also produced tracks for Kula Shaker and served as a music supervisor for a number of movies, including Blades of Glory, School of Rock, Star Trek, Team America: World Police, Tropic Thunder, The Runaways, Zodiac, The Hangover, The Hangover Part II and Super 8.
- Drakoulias is mentioned in the "Stop That Train" section of the song B-Boy Bouillabaisse on the Beastie Boys album Paul's Boutique in the lyric, "Sat across from my man reading El Diario, riding the train down from the El Barrio. Went from the station, to Orange Julius, I brought a hot dog from who? George Drakoulias."
- The character Oseary Drakoulias in the film The Life Aquatic with Steve Zissou is named after Drakoulias and Guy Oseary.
- The character Big George Drakoulias, played by Billy Bob Thornton in the film Dead Man, is named after Drakoulias. (Jared Harris, incidentally, plays a character named after Benmont Tench of the Heartbreakers in the same film.)
- In a nod to his work on Star Trek, an alien predator which hunts down young James T. Kirk on Delta Vega (in the novelization of the film, Kirk describes it as the "bastard offspring" of a polar bear and a gorilla) is officially named the drakoulias.
- (1990) Shake your Money Maker, The Black Crowes
- (1991) White Trash, White Trash
- (1992) The Southern Harmony and Musical Companion, The Black Crowes
- (1992) Hollywood Town Hall, The Jayhawks
- (1993) You Gotta Sin to Get Saved, Maria McKee
- (1994) Give Out But Don't Give Up, Primal Scream
- (1994) Carnival of Light, Ride ("How Does It Feel To Feel?")
- (1995) Tomorrow the Green Grass, The Jayhawks
- (1996) Dust, Screaming Trees
- (1997) Glow, Reef
- (1998) No. 4 Record, You Am I
- (2002) The Red Record, Loudermilk
- (2002) The Last DJ, Tom Petty and the Heartbreakers
- (2004) Tambourine, Tift Merritt
- (2005) The Deep End, Madrugada
- (2006) The Believer, Rhett Miller
- (2007) 8 Diagrams, Wu-Tang Clan ("The Heart Gently Weeps", "Weak Spot")
- (2007) Low Stars, Low Stars
- (2008) Another Country, Tift Merritt
- (2008) You Can Do Anything, The Zutons
- (2008) Back to the River, Susan Tedeschi
- (2012) Blind Sighted Faith, The Dunwells ("So Beautiful")
- (2014) She's Funny That Way (Producer)