Although Blood, Sweat & Tears continued to record and tour for several more years, the band's lineup changed dramatically after Blood, Sweat & Tears 4. This compilation album includes all of the group's best-known material, and it was their last album to go gold. Columbia initially chose to incorporate the single edits of the radio hits, a decision which was poorly received by some fans; later CD releases extended the singles to full-length album versions.
Writing for Allmusic, critic William Ruhlman wrote the album "captures the band's peak in 11 selections—seven singles chart entries, plus two album tracks from the celebrated debut album when Al Kooper helmed the group, and two more from the Grammy-winning multi-platinum second album... For the millions who learned to love BS&T in 1969 when they were all over AM radio, this is the ideal selection of their most accessible material." Music critic Robert Christgau's commented "their pop success does them more good in Vegas than on the radio, and only four of these eleven cuts made top twenty."