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CAS number 520-33-2 YesY
PubChem 72281
ChemSpider 65234 YesY
UNII Q9Q3D557F1 YesY
EC number 208-290-2
DrugBank DB01094
KEGG C01709 YesY
ChEBI CHEBI:28230 YesY
Jmol-3D images Image 1
Molecular formula C16H14O6
Molar mass 302.27 g/mol
Melting point 226–228 °C
Solubility in other solvents Sol. EtOH, alkalis
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

Hesperetin is a bioflavonoid and, to be more specific, a flavanone. Hesperidin (a flavonone glycoside) is water-soluble due to the presence of the sugar part in its structure, so on ingestion it releases its aglycone, i.e., hesperetin.
Hesperidin is found in Citrus fruits.


Hesperidin is a water-insoluble flavonoid glycoside whose solubility is below 5 μg/ml in water.[1]

Neohesperidin is the 7-neohesperidoside of hesperetin.

Hesperetin 7-rhamnoside can be isolated from Cordia obliqua.[2]


Hesperidin 6-O-alpha-L-rhamnosyl-beta-D-glucosidase is an enzyme that uses hesperidin and H2O to produce hesperetin and rutinose. It is found in the hyphomycetes species Stilbella fimetaria.


  1. ^ Majumdar S.; Srirangam, R. Solubility, stability, physicochemical characteristics and in vitro ocular tissue permeability of hesperidin: a natural bioflavonoid. Pharm Res., 2009, 26, 1217–1225.
  2. ^ Hesperetin 7-rhamnoside from Cordia obliqua. J.S. Chauhan, S.K. Srivastava and M. Sultan, Phytochemistry, 1978, Volume 17, Issue 2, Page 334, doi:10.1016/S0031-9422(00)94187-6