Medications that are given as hormone replacement therapy following a complete hypophysectomy (removal of the pituitary gland) are often glucocorticoids. Secondary Addison's and hyperlipidemia can occur. Thyroid hormone is useful in controlling cholesterol metabolism that has been affected by pituitary deletion.
Hypophysectomy performed at any age causes atrophy of the thyroid and adrenal glands as well as asthenia and cachexia. When the procedure is performed before sexual maturity, the reproductive tract remains undeveloped and non-functional. There is also a general lack of growth. If performed after sexual maturity, there will be a loss of reproductive function along with atrophy of gonads and accessory reproductive structures. There is a risk of Cerebral Spinal fluid leak due to penetration of the basal skull,risk of Increase cerebral spinal fluid pressure that may lead to Central Nervous system changes. Increased risk of hemorrhage and infection secondary to the surgical procedure. Post surgery patients may have a severely altered self-image that may lead to an increased the risk of suicide.