"Isn't Life Strange" opens with a slow duet of the flute (played by Ray Thomas) and a pump organ, otherwise known as a harmonium, (played by Mike Pinder), with John Lodge and Justin Hayward providing vocals. The song's chorus features the band's traditional line-up, and vocals provided by Hayward, Lodge, Pinder, and Thomas.
When the Moody Blues perform "Isn't Life Strange" live, John Lodge uses a double neck guitar with a standard 6-string on one neck, and a 4-string bass on the other. He uses this since he generally plays the 6-string guitar during the verses, and the bass during the chorus since Justin Hayward takes over electric guitar during the chorus. Also, whenever the Moody Blues perform live backed by a full orchestra, the orchestra's brass section performs a solo of the chorus twice throughout the song, once in the middle, and once at the end.
The original version of "Isn't Life Strange" is extended by two minutes and includes a slow instrumental duet of Ray Thomas' flute and Mike Pinder's Chamberlin which was deleted, possibly due to time restraints. For the re-issue of "Seventh Sojourn" this version has been restored and added as a bonus track.
"Isn't Life Strange" is one of the Moody Blues' most popular songs, and has been included in virtually all of their compilation and live albums. In addition, the song was re-recorded (along with "Question") in the studio with an orchestra in 1988, for the Greatest Hits album.