When she joined Sun Ra's Arkestra around 1968, she became the first female member of his band. (Sun Ra had previously recorded with a few female vocalists, but they were not members of his band.) She became a close and trusted friend of Ra, and helped him with costume design. Tyson continued to perform and record with Ra up to her death.
Tyson was diagnosed with cancer and grew increasingly ill. When she was unable to sing because of her illness, she played the violin.