Upon release, the album debuted in the top 10 in many countries around the world and the first single "Remedy" held the top spot on the BillboardMainstream Rock Tracks chart. Following singles "Truth," and "The Gift", though not to the same extent, also found success on rock radio. Since its release the album has sold 635,412 units in the U.S. and nearly 800,000 worldwide. It is widely regarded as their magnum opus.
Before the release of Karma and Effect, a blog from the band on their website stated that there would be three b-side tracks for the album. They are: "Let Me Go", "Innocence" and "Blister". "Let Me Go" has been released and can be found on the "Remedy" single. "Innocence" and "Blister" were never mixed or mastered, but both songs, likely obtained off the album's demo tapes, were made available on a fan site for a short time. All of these songs were eventually included on the second disc of their greatest hits album, Seether: 2002-2013.