LASS1
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| LAG1 homolog, ceramide synthase 1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | LASS1; CerS1; LAG1; MGC90349; UOG1 | ||||||||||||
| External IDs | OMIM: 606919 MGI: 2136690 HomoloGene: 23297 GeneCards: LASS1 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10715 | 93898 | |||||||||||
| Ensembl | ENSG00000223802 | ENSMUSG00000087408 | |||||||||||
| UniProt | P27544 | n/a | |||||||||||
| RefSeq (mRNA) | NM_021267.3 | NM_138647.3 | |||||||||||
| RefSeq (protein) | NP_067090.1 | NP_619588.1 | |||||||||||
| Location (UCSC) | Chr 19: 18.98 – 19.01 Mb |
Chr 8: 72.84 – 72.86 Mb |
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| PubMed search | [1] | [2] | |||||||||||
LAG1 longevity assurance homolog 1 is a protein that in humans is encoded by the LASS1 gene.[1][2][3]
This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. Members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in yeast suggest that the encoded protein is involved in aging. This protein is transcribed from a monocistronic mRNA as well as a bicistronic mRNA, which also encodes growth differentiation factor 1.[3]
[edit] References
- ^ Jiang JC, Kirchman PA, Zagulski M, Hunt J, Jazwinski SM (Jun 1999). "Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human". Genome Res 8 (12): 1259–72. doi:10.1101/gr.8.12.1259. PMID 9872981.
- ^ Lee SJ (Jun 1991). "Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure". Proc Natl Acad Sci U S A 88 (10): 4250–4. doi:10.1073/pnas.88.10.4250. PMC 51636. PMID 2034669. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=51636.
- ^ a b "Entrez Gene: LASS1 LAG1 homolog, ceramide synthase 1 (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10715.
[edit] Further reading
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Koybasi S, Senkal CE, Sundararaj K, et al. (2004). "Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas". J. Biol. Chem. 279 (43): 44311–9. doi:10.1074/jbc.M406920200. PMID 15317812.
- Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Venkataraman K, Riebeling C, Bodennec J, et al. (2002). "Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells". J. Biol. Chem. 277 (38): 35642–9. doi:10.1074/jbc.M205211200. PMID 12105227.
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