Acetyl-CoA C-acyltransferase

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acetyl-CoA C-acyltransferase
Identifiers
EC number 2.3.1.16
CAS number 9029-97-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

The final step of beta oxidation is the cleavage of 3-ketoacyl CoA by the thiol group of another molecule of Coenzyme A. This reaction is catalyzed by Acetyl-CoA C-acyltransferase (or Β-ketothiolase). The thiol is inserted between C-2 and C-3, which yields an acetyl CoA molecule and an acyl CoA molecule, which is two carbons shorter.

Acetyl-CoA C-acyltransferase belongs to the thiolase family of enzymes.

FattyAcid-MB-Thiolysis.png

Examples[edit]

Human genes that encode acetyl-CoA C-acyltransferases include:

acetyl-CoA acyltransferase 1 (peroxisomal)
Identifiers
Symbol ACAA1
Entrez 30
HUGO 82
OMIM 604054
RefSeq NM_001607
UniProt P09110
Other data
Locus Chr. 3 p23-p22
acetyl-CoA acyltransferase 2 (mitochondrial)
Identifiers
Symbol ACAA2
Entrez 10449
HUGO 83
OMIM 604770
RefSeq NM_006111
UniProt P42765
Other data
Locus Chr. 18 q21
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
Identifiers
Symbol HADHB
Entrez 3032
HUGO 4803
OMIM 143450
RefSeq NM_000183
UniProt P55084
Other data
Locus Chr. 2 p23

External links[edit]