Laninamivir

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Laninamivir
Laninamivir.svg
Systematic (IUPAC) name
(4S,5R,6R)-5-acetamido-4-carbamimidamido-6-[(1R,2R)-3-hydroxy-2-methoxypropyl]-5,6-dihydro-4H-pyran-2-carboxylic acid
Clinical data
Legal status ?
Routes Inhalation
Identifiers
CAS number 203120-17-6 N
ATC code None
PubChem CID 502272
ChemSpider 439182 YesY
UNII B408IW3GL5 YesY
ChEMBL CHEMBL466246 YesY
Chemical data
Formula C13H22N4O7 
Mol. mass 346.33638 g/mol
 N (what is this?)  (verify)

Laninamivir (CS-8958) is a neuraminidase inhibitor which is being researched for the treatment and prophylaxis of Influenzavirus A and Influenzavirus B.[1] It is currently in Phase III clinical trials.[2] It is a long-acting neuraminidase inhibitor administered by nasal inhalation.[3]

Laninamivir was approved for influenza treatment in Japan in 2010 and for prophylaxis in 2013. It is currently marketed under the name "Inavir" by Daiichi Sankyo. Biota Pharmaceuticals [4] and Daiichi Sankyo co-own Laninamivir. On 1 April 2011, BARDA awarded up to an estimated U$231m to Biota Pharmaceuticals (Formerly Biota Holdings Ltd) wholly owned subsidiary, Biota Scientific Management Pty Ltd, for the advanced development of Laninamivir in the US.[5] It is under clinical evaluations in other countries.[3]

References[edit]

  1. ^ Yamashita M, Tomozawa T, Kakuta M, Tokumitsu A, Nasu H, Kubo S (January 2009). "CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity". Antimicrobial Agents and Chemotherapy 53 (1): 186–92. doi:10.1128/AAC.00333-08. PMC 2612152. PMID 18955520. 
  2. ^ Hayden F (January 2009). "Developing new antiviral agents for influenza treatment: what does the future hold?". Clinical Infectious Diseases. 48. Suppl 1 (S1): S3–13. doi:10.1086/591851. PMID 19067613. 
  3. ^ a b Samson, M; Pizzorno, A; Abed, Y; Boivin, G (May 2013). "Influenza virus resistance to neuraminidase inhibitors.". Antiviral research 98 (2): 174–85. PMID 23523943. 
  4. ^ http://www.biotapharma.com
  5. ^ http://www.biotapharma.com/?page=1021001&subpage=1021019