Laninamivir

Laninamivir
Systematic (IUPAC) name
	(4S,5R,6R)-5-acetamido-4-carbamimidamido-6-[(1R,2R)-3-hydroxy-2-methoxypropyl]-5,6-dihydro-4H-pyran-2-carboxylic acid
Clinical data
Pregnancy cat.	?
Legal status	?
Routes	Inhalation
Identifiers
CAS number	203120-17-6
ATC code	None
PubChem	CID 502272
ChemSpider	439182
UNII	B408IW3GL5
ChEMBL	CHEMBL466246
Chemical data
Formula	C13H22N4O7
Mol. mass	346.33638 g/mol
SMILES	eMolecules & PubChem
	InChI InChI=1S/C13H22N4O7/c1-5(19)16-9-6(17-13(14)15)3-8(12(21)22)24-11(9)10(23-2)7(20)4-18/h3,6-7,9-11,18,20H,4H2,1-2H3,(H,16,19)(H,21,22)(H4,14,15,17)/t6-,7+,9+,10+,11+/m0/s1 ; Key:QNRRHYPPQFELSF-CNYIRLTGSA-N ;
(what is this?) (verify);

Laninamivir (CS-8958) is a neuraminidase inhibitor which is being researched for the treatment and prophylaxis of Influenzavirus A and Influenzavirus B.^[1] It is currently in Phase III clinical trials. ^[2]

Laninamivir was approved for influenza treatment in Japan in 2010 and is currently marketed under the name "Inavir" by Daiichi Sankyo. Biota Holdings Ltd and Daiichi Sankyo co-own Laninamivir. On 1st April 2011, BARDA awarded up to an estimated U$231m to Biota Holdings Ltd's wholly owned subsidiary, Biota Scientific Management Pty Ltd, for the advanced development of Laninamivir in the US. ^[3]

[edit] References

^ Yamashita M, Tomozawa T, Kakuta M, Tokumitsu A, Nasu H, Kubo S (January 2009). "CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity". Antimicrobial Agents and Chemotherapy 53 (1): 186–92. doi:10.1128/AAC.00333-08. PMC 2612152. PMID 18955520. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2612152.
^ Hayden F (January 2009). "Developing new antiviral agents for influenza treatment: what does the future hold?". Clinical Infectious Diseases. 48 Suppl 1 (S1): S3–13. doi:10.1086/591851. PMID 19067613.
^ www.biota.com.au

This antiinfective drug article is a stub. You can help Wikipedia by expanding it.

[pmid18955520-0] Yamashita M, Tomozawa T, Kakuta M, Tokumitsu A, Nasu H, Kubo S (January 2009). "CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity". Antimicrobial Agents and Chemotherapy 53 (1): 186–92. doi:10.1128/AAC.00333-08. PMC 2612152. PMID 18955520. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2612152.

[pmid19067613-1] Hayden F (January 2009). "Developing new antiviral agents for influenza treatment: what does the future hold?". Clinical Infectious Diseases. 48 Suppl 1 (S1): S3–13. doi:10.1086/591851. PMID 19067613.

[Biota_Holdings_Ltd-2] www.biota.com.au

[1]

[2]

[3]

Laninamivir

[edit] References

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Interaction

Toolbox

Print/export

Languages