Lipopolysaccharide binding protein

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Lipopolysaccharide binding protein
Identifiers
Symbols LBP ; BPIFD2
External IDs OMIM151990 MGI1098776 HomoloGene3055 GeneCards: LBP Gene
RNA expression pattern
PBB GE LBP 214461 at tn.png
PBB GE LBP 211652 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3929 16803
Ensembl ENSG00000129988 ENSMUSG00000016024
UniProt P18428 Q61805
RefSeq (mRNA) NM_004139 NM_008489
RefSeq (protein) NP_004130 NP_032515
Location (UCSC) Chr 20:
36.97 – 37.01 Mb
Chr 2:
158.31 – 158.33 Mb
PubMed search [1] [2]

Lipopolysaccharide binding protein is a protein that in humans is encoded by the LBP gene.[1][2]

LBP is a soluble acute-phase protein that binds to bacterial lipopolysaccharide (or LPS) to elicit immune responses by presenting the LPS to important cell surface pattern recognition receptors called CD14 and TLR4.[3]

The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene.[2]

Interactions[edit]

Lipopolysaccharide-binding protein has been shown to interact with CD14, TLR2, TLR4 and the co-receptor MD-2.[4][5][6]

References[edit]

  1. ^ Gray PW, Corcorran AE, Eddy RL Jr, Byers MG, Shows TB (March 1993). "The genes for the lipopolysaccharide binding protein (LBP) and the bactericidal permeability increasing protein (BPI) are encoded in the same region of human chromosome 20". Genomics 15 (1): 188–90. doi:10.1006/geno.1993.1030. PMID 8432532. 
  2. ^ a b "Entrez Gene: LBP lipopolysaccharide binding protein". 
  3. ^ Muta T, Takeshige K (2001). "Essential roles of CD14 and lipopolysaccharide-binding protein for activation of toll-like receptor (TLR)2 as well as TLR4 Reconstitution of TLR2- and TLR4-activation by distinguishable ligands in LPS preparations". Eur. J. Biochem. 268 (16): 4580–9. doi:10.1046/j.1432-1327.2001.02385.x. PMID 11502220. 
  4. ^ Thomas, Celestine J; Kapoor Mili; Sharma Shilpi; Bausinger Huguette; Zyilan Umit; Lipsker Dan; Hanau Daniel; Surolia Avadhesha (November 2002). "Evidence of a trimolecular complex involving LPS, LPS binding protein and soluble CD14 as an effector of LPS response". FEBS Lett. (Netherlands) 531 (2): 184–8. doi:10.1016/S0014-5793(02)03499-3. ISSN 0014-5793. PMID 12417309. 
  5. ^ Yu, B; Wright S D (1995). "LPS-dependent interaction of Mac-2-binding protein with immobilized CD14". J. Inflamm. (UNITED STATES) 45 (2): 115–25. ISSN 1078-7852. PMID 7583357. 
  6. ^ Erridge, C; Pridmore, A; Eley, A; Stewart, J; Poxton, IR (2004). "Lipopolysaccharides of Bacteroides fragilis, Chlamydia trachomatis and Pseudomonas aeruginosa signal via toll-like receptor 2.". Journal of Medical Microbiology 53 (Pt 8): 735–40. doi:10.1099/jmm.0.45598-0. PMID 15272059. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.