MUTYH

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MutY homolog
Protein MUTYH PDB 1x51.png
PDB rendering based on 1x51.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MUTYH ; MYH
External IDs OMIM604933 MGI1917853 HomoloGene8156 GeneCards: MUTYH Gene
EC number 3.2.2.-
RNA expression pattern
PBB GE MUTYH 207727 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4595 70603
Ensembl ENSG00000132781 ENSMUSG00000028687
UniProt Q9UIF7 Q99P21
RefSeq (mRNA) NM_001048171 NM_001159581
RefSeq (protein) NP_001041636 NP_001153053
Location (UCSC) Chr 1:
45.79 – 45.81 Mb
Chr 4:
116.81 – 116.82 Mb
PubMed search [1] [2]

MUTYH (mutY Homolog (E. coli)) is a human gene encoding a DNA glycosylase, MUTYH glycosylase, involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[1]

The MUTYH gene is located on the short (p) arm of chromosome 1 between positions 34.3 and 32.1, from base pair 45,464,007 to base pair 45,475,152.

Related conditions[edit]

Mutations in the MUTYH gene cause an autosomal recessive form of familial adenomatous polyposis (also called MUTYH-associated polyposis). Polyps caused by mutated MUTYH do not appear until adulthood and are less numerous than those found in patients with APC gene mutations.

Mutations in this gene affect the ability of cells to correct mistakes made during DNA replication. Both copies of the MYH gene are mutated in individuals who have autosomal recessive familial adenomatous polyposis. Most reported mutations in this gene cause production of a nonfunctional or low functioning glycosylase enzyme. When base excision repair in the cell is compromised, mutations in other genes build up, leading to cell overgrowth and possibly tumor formation. The two most common mutations in Caucasian Europeans are exchanges of amino acids (the building blocks of proteins) in the enzyme. One mutation replaces the amino acid tyrosine with cysteine at position 165 (also written as Tyr165Cys or Y165C). The other common mutation switches the amino acid glycine with aspartic acid at position 382 (also written as Gly382Asp or G382D).

Interactions[edit]

MUTYH has been shown to interact with Replication protein A1,[2] PCNA[2] and APEX1.[2]

References[edit]

  1. ^ "Entrez Gene: MUTYH mutY homolog (E. coli)". 
  2. ^ a b c Parker, A; Gu Y; Mahoney W; Lee S H; Singh K K; Lu A L (Feb 2001). "Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair". J. Biol. Chem. (United States) 276 (8): 5547–55. doi:10.1074/jbc.M008463200. ISSN 0021-9258. PMID 11092888. 

Further reading[edit]

  • Cheadle JP, Sampson JR (2003). "Exposing the MYtH about base excision repair and human inherited disease". Hum Mol Genet. 12 Spec No 2 (90002): R159–65. doi:10.1093/hmg/ddg259. PMID 12915454. 
  • Croitoru ME, Cleary SP, Di Nicola N, Manno M, Selander T, Aronson M, Redston M, Cotterchio M, Knight J, Gryfe R, Gallinger S (2004). "Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer risk". J Natl Cancer Inst 96 (21): 1631–4. doi:10.1093/jnci/djh288. PMID 15523092. 
  • Fleischmann C, Peto J, Cheadle J, Shah B, Sampson J, Houlston RS (2004). "Comprehensive analysis of the contribution of germline MYH variation to early-onset colorectal cancer". Int J Cancer 109 (4): 554–8. doi:10.1002/ijc.20020. PMID 14991577. 
  • Jones S, Emmerson P, Maynard J, Best JM, Jordan S, Williams GT, Sampson JR, Cheadle JP (2002). "Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C-->T:A mutations". Hum Mol Genet 11 (23): 2961–7. doi:10.1093/hmg/11.23.2961. PMID 12393807. 
  • Jones S, Lambert S, Williams GT, Best JM, Sampson JR, Cheadle JP (2004). "Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas". Br J Cancer 90 (8): 1591–3. doi:10.1038/sj.bjc.6601747. PMC 2410274. PMID 15083190. 
  • Kambara T, Whitehall VL, Spring KJ, Barker MA, Arnold S, Wynter CV, Matsubara N, Tanaka N, Young JP, Leggett BA, Jass JR (2004). "Role of inherited defects of MYH in the development of sporadic colorectal cancer". Genes Chromosomes Cancer 40 (1): 1–9. doi:10.1002/gcc.20011. PMID 15034862. 
  • Lipton L, Halford SE, Johnson V, Novelli MR, Jones A, Cummings C, Barclay E, Sieber O, Sadat A, Bisgaard ML, Hodgson SV, Aaltonen LA, Thomas HJ, Tomlinson IP (2003). "Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway". Cancer Res 63 (22): 7595–9. PMID 14633673. 
  • Sampson JR, Dolwani S, Jones S, Eccles D, Ellis A, Evans DG, Frayling I, Jordan S, Maher ER, Mak T, Maynard J, Pigatto F, Shaw J, Cheadle JP (2003). "Autosomal recessive colorectal adenomatous polyposis due to inherited mutations of MYH". Lancet 362 (9377): 39–41. doi:10.1016/S0140-6736(03)13805-6. PMID 12853198. 
  • Sieber OM, Lipton L, Crabtree M, Heinimann K, Fidalgo P, Phillips RK, Bisgaard ML, Orntoft TF, Aaltonen LA, Hodgson SV, Thomas HJ, Tomlinson IP (2003). "Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH". N Engl J Med 348 (9): 791–9. doi:10.1056/NEJMoa025283. PMID 12606733. 
  • Venesio T, Molatore S, Cattaneo F, Arrigoni A, Risio M, Ranzani GN (2004). "High frequency of MYH gene mutations in a subset of patients with familial adenomatous polyposis". Gastroenterology 126 (7): 1681–5. doi:10.1053/j.gastro.2004.02.022. PMID 15188161. 
  • Wang L, Baudhuin LM, Boardman LA, Steenblock KJ, Petersen GM, Halling KC, French AJ, Johnson RA, Burgart LJ, Rabe K, Lindor NM, Thibodeau SN (2004). "MYH mutations in patients with attenuated and classic polyposis and with young-onset colorectal cancer without polyps". Gastroenterology 127 (1): 9–16. doi:10.1053/j.gastro.2004.03.070. PMID 15236166. 

External links[edit]