MRS owned railroad cars used to transport Anheuser-Busch's products. It also provided locomotive maintenance and painting services to other companies.
On March 25, 2011, it was announced that Anheuser-Busch had applied to shut down the MRS, after the brewery began shipping outbound products via truck instead of rail. However, on April 8, Foster Townsend Rail Logistics (reporting marks: FTRL) announced that it planned to take over operations of the line once Manufacturers Railway ceased operations. On October 2, 2011, FTRL Railway began providing rail switching services at Anheuser Busch's St. Louis brewery.