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Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
External IDs OMIM604548 MGI1194908 HomoloGene36160 ChEMBL: 3407 GeneCards: NFKBIE Gene
RNA expression pattern
PBB GE NFKBIE 203927 at tn.png
More reference expression data
Species Human Mouse
Entrez 4794 18037
Ensembl ENSG00000146232 ENSMUSG00000023947
UniProt O00221 O54910
RefSeq (mRNA) NM_004556 NM_008690
RefSeq (protein) NP_004547 NP_032716
Location (UCSC) Chr 6:
44.23 – 44.23 Mb
Chr 17:
45.56 – 45.56 Mb
PubMed search [1] [2]

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon, also known as NFKBIE, is a protein which in humans is encoded by the NFKBIE gene.[1][2]


NFKBIE protein expression is up-regulated following NF-κB activation and during myelopoiesis. NFKBIE is able to inhibit NF-κB-directed transactivation via cytoplasmic retention of REL proteins.[2]

NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-κB transcription factor complex. The NF-κB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NF-κB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For some genes, activation requires NF-κB interaction with other transcription factors, such as STAT (see STAT6), AP-1 (JUN), and NFAT (see NFATC1).[1]


NFKBIE has been shown to interact with NFKB2,[3] RELA,[3] NFKB1[3] and REL.[3][4][5]


  1. ^ a b "Entrez Gene: NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon". 
  2. ^ a b Whiteside ST, Epinat JC, Rice NR, Israël A (March 1997). "I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity". EMBO J. 16 (6): 1413–26. doi:10.1093/emboj/16.6.1413. PMC 1169738. PMID 9135156. 
  3. ^ a b c d Li, Z; Nabel G J (October 1997). "A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription". Mol. Cell. Biol. (United States) 17 (10): 6184–90. ISSN 0270-7306. PMC 232469. PMID 9315679. 
  4. ^ Kumar, S; Gélinas C (October 1993). "I kappa B alpha-mediated inhibition of v-Rel DNA binding requires direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motif". Proc. Natl. Acad. Sci. U.S.A. (United States) 90 (19): 8962–6. doi:10.1073/pnas.90.19.8962. ISSN 0027-8424. PMC 47481. PMID 8415639. 
  5. ^ Spiecker, M; Darius H; Liao J K (March 2000). "A functional role of I kappa B-epsilon in endothelial cell activation". J. Immunol. (United States) 164 (6): 3316–22. ISSN 0022-1767. PMID 10706725. 

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