NFKBIE

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Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
Identifiers
Symbols NFKBIE ; IKBE
External IDs OMIM604548 MGI1194908 HomoloGene36160 ChEMBL: 3407 GeneCards: NFKBIE Gene
RNA expression pattern
PBB GE NFKBIE 203927 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4794 18037
Ensembl ENSG00000146232 ENSMUSG00000023947
UniProt O00221 O54910
RefSeq (mRNA) NM_004556 NM_008690
RefSeq (protein) NP_004547 NP_032716
Location (UCSC) Chr 6:
44.23 – 44.23 Mb
Chr 17:
45.56 – 45.56 Mb
PubMed search [1] [2]

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon, also known as NFKBIE, is a protein which in humans is encoded by the NFKBIE gene.[1][2]

Function[edit]

NFKBIE protein expression is up-regulated following NF-κB activation and during myelopoiesis. NFKBIE is able to inhibit NF-κB-directed transactivation via cytoplasmic retention of REL proteins.[2]

NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-κB transcription factor complex. The NF-κB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NF-κB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For some genes, activation requires NF-κB interaction with other transcription factors, such as STAT (see STAT6), AP-1 (JUN), and NFAT (see NFATC1).[1]

Interactions[edit]

NFKBIE has been shown to interact with NFKB2,[3] RELA,[3] NFKB1[3] and REL.[3][4][5]

References[edit]

  1. ^ a b "Entrez Gene: NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon". 
  2. ^ a b Whiteside ST, Epinat JC, Rice NR, Israël A (March 1997). "I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity". EMBO J. 16 (6): 1413–26. doi:10.1093/emboj/16.6.1413. PMC 1169738. PMID 9135156. 
  3. ^ a b c d Li, Z; Nabel G J (October 1997). "A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription". Mol. Cell. Biol. (United States) 17 (10): 6184–90. ISSN 0270-7306. PMC 232469. PMID 9315679. 
  4. ^ Kumar, S; Gélinas C (October 1993). "I kappa B alpha-mediated inhibition of v-Rel DNA binding requires direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motif". Proc. Natl. Acad. Sci. U.S.A. (United States) 90 (19): 8962–6. doi:10.1073/pnas.90.19.8962. ISSN 0027-8424. PMC 47481. PMID 8415639. 
  5. ^ Spiecker, M; Darius H; Liao J K (March 2000). "A functional role of I kappa B-epsilon in endothelial cell activation". J. Immunol. (United States) 164 (6): 3316–22. ISSN 0022-1767. PMID 10706725. 

Further reading[edit]