Nakhtpaaten seems to have succeeded the Vizier Ramose in office. Ramose was the vizier in Thebes possibly up to the time of the move to Akhetaten, Akhenaten's new capitol. Ramose's tomb in Thebes was not finished and after the move to the new city in year 4-5 of Akhenaten Nakhtpaaten is the vizier. His titles as given in his house and tomb were: Hereditary prince, count, sealbearer, overseer of the city and vizier, overseer of the work projects in Akhet-Aten.
It is likely Nakhtpaaten who is depicted in the tomb of Mahu who served as the Chief of Police. Mahu is shown meeting with a vizier and a lesser official named Heqanefer in a scene related to policing the city.
He lived in the southern city part of Akhet-Aten, his house has been found. Nakhtpaaten's house was a large mansion which included reception halls, bedrooms, a bathroom, a lavatory and offices.